ArticleNature microbiology2017
D-Alanylation of teichoic acids contributes to Lactobacillus plantarum-mediated Drosophila growth during chronic undernutrition.
Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 119 citations in OpenAlex.
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- Spatiotemporal dynamics of mucosa-associatedAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Commensal bacterial glycosylation at the interface of host-bacteria interactions.Gut microbes · 2025Review
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- Environment and diet shape the geography-specificApplied and environmental microbiology · 2025Article
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- Unveiling diversity and adaptations of the wild tomato Microbiome in their center of origin in the Ecuadorian Andes.Scientific reports · 2025Article
- Gut microbiome and host TOR pathway interact to regulate predator-induced aversive memory inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Acyltransferases that Modify Cell Surface Polymers Across the Membrane.Biochemistry · 2025Review
- Distinct effects of two dominant enteric bacteria on the developmental performance of spodoptera frugiperda and their association with physiological metabolism.Scientific reports · 2025Article
- Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila.Nature communications · 2025Article
- Intestinal commensal bacteria promote Bactrocera dorsalis larval development through the vitamin B6 synthesis pathway.Microbiome · 2024Article
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- Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles.Scientific reports · 2024Article
- Gut microbiota in regulation of childhood bone growth.Experimental physiology · 2024Review
- Adsorption Characterization of Lactobacillus sp. for Di-(2-ethylhexyl) phthalate.Probiotics and antimicrobial proteins · 2024Article
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- Significant role of symbiotic bacteria in the blood digestion and reproduction ofISME communications · 2024Article
- Massively parallel mutant selection identifies genetic determinants ofbioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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12 authors at 2 institutions in 1 country.
Funding
Abstract
The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth and maturation partly through enhanced expression of intestinal peptidases. By screening a transposon insertion library of Lactobacillus plantarum in gnotobiotic Drosophila larvae, we identify a bacterial cell-wall-modifying machinery encoded by the pbpX2-dlt operon that is critical to enhance host digestive capabilities and promote animal growth and maturation. Deletion of this operon leads to bacterial cell wall alteration with a complete loss of D-alanylation of teichoic acids. We show that L. plantarum cell walls bearing D-alanylated teichoic acids are directly sensed by Drosophila enterocytes to ensure optimal intestinal peptidase expression and activity, juvenile growth and maturation during chronic undernutrition. We thus conclude that besides peptidoglycan, teichoic acid modifications participate in the host-commensal bacteria molecular dialogue occurring in the intestine.
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