Evidence map›Paper›PMID 28993610›Full record

ArticleNature microbiology2017

Evolution of host adaptation in the Salmonella typhoid toxin.

Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki, Jorge E Galán

Erratum issuedAbstract read
In one paragraph

Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. An RNase III-processed sRNA coordinates sialic acid metabolism ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Article
  7. The diverse landscape of AB5-type toxins.Engineering microbiology · 2023
    Review
  8. Review
  9. Evolution of insect innate immunity through domestication of bacterial toxins.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Sialoglycan-binding patterns of bacterial ABThe Journal of biological chemistry · 2022
    Article
  11. Article
  12. ABToxins · 2022
    Review
  13. The evolutionary diversification of theFrontiers in microbiology · 2022
    Article
  14. Cellular Activity ofToxins · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiang GaoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, 06536, USA.
Lingquan DengGlycobiology Research and Training Center, Departments of Medicine, Pathology and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Gabrielle StackDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, 06536, USA.
Hai YuDepartment of Chemistry, University of California Davis, Davis, CA, 95616, USA.
Xi ChenDepartment of Chemistry, University of California Davis, Davis, CA, 95616, USA.
Yuko Naito-MatsuiGlycobiology Research and Training Center, Departments of Medicine, Pathology and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Ajit VarkiGlycobiology Research and Training Center, Departments of Medicine, Pathology and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-2206-975X
Jorge E GalánDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, 06536, USA. jorge.galan@yale.edu.ORCID http://orcid.org/0000-0002-6531-0355
University of California San Diego · USYale University · USUniversity of California, Davis · US

Funding

BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
Typhoid Toxin and Salmonella Typhi pathogenesisR01AI114618 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2014 to 2023
$5.4M
Virulence factors of Salmonella TyphiR01AI079022 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2008 to 2012
$2.0M
BIOLOGY OF SIALIC ACIDS AND THEIR SUBSTITUTIONSR37GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI VARKI, AJIT P · 1995 to 2004
$1.8M
Virulence factors of Salmonella TyphiR56AI079022 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2014 to 2014
$486k
Upgrade of a home source macromolecular X-ray diffraction system.S10OD018007 · OD · YALE UNIVERSITY · PI BOGGON, TITUS JONATHON · 2014 to 2014
$460k
NIAID NIH HHS R01 AI079022NIAID NIH HHS R01 AI114618NIAID NIH HHS R56 AI079022NIGMS NIH HHS R01 GM032373NIGMS NIH HHS R37 GM032373NIH HHS S10 OD018007
6 · The paper itself

Abstract

The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host

Indexed as

Adaptation, PhysiologicalAmino Acid SequenceAnimalsBacterial ProteinsBacterial ToxinsBinding SitesCell LineCrystallography, X-RayEndotoxinsGlycomicsHEK293 CellsHost SpecificityHumansMaleMiceModels, MolecularBacterial ProteinsBacterial ToxinsCdtB protein, Salmonella typhimuriumcytolethal distending toxinEndotoxinsN-Acetylneuraminic AcidNeuraminic AcidsN-glycolylneuraminic acidPltA protein, Salmonella typhimuriumPolysaccharidessalmonella toxinTranscription FactorsVirulence Factors

Identifiers

PMID28993610
PMCPMC5705260
OpenAlexW2763261402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.