ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Flexible clock systems: adjusting the temporal programme.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Are cyclic plant and animal behaviours driven by gravimetric mechanical forces?Journal of experimental botany · 2022Pooled it
- A cellular basis for the mammalian nocturnal-diurnal switch.Science (New York, N.Y.) · 2026Article
- Simulated natural daylight and twilight modulate activity and light sampling behaviour in mice.BMC biology · 2026Article
- Simulated natural daylight and twilight modulate activity and light sampling behaviour in mice.BMC biology · 2026Article
- Biting time of day in malaria mosquitoes is modulated by nutritional status.Malaria journal · 2025Article
- Biting time of day in malaria mosquitoes is modulated by nutritional status.bioRxiv : the preprint server for biology · 2025Article
- Seasonal plasticity in daily timing of flight activity inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Light sampling behaviour regulates circadian entrainment in mice.BMC biology · 2024Article
- Energy balance drives diurnal and nocturnal brain transcriptome rhythms.Cell reports · 2024Article
- Endocrine-circadian interactions in birds: implications when nights are no longer dark.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Songbirds initiate migratory flights synchronously relative to civil dusk.Movement ecology · 2023Article
- Perfecting the Life Clock: The Journey from PTO to TTFL.International journal of molecular sciences · 2023Review
- No relationship between chronotype and timing of breeding when variation in daily activity patterns across the breeding season is taken into account.Ecology and evolution · 2022Article
- Mistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice.Hormones and behavior · 2022Article
- After 55 Years of Neurorehabilitation, What Is the Plan?Brain sciences · 2022Review
- Sticky Pi is a high-frequency smart trap that enables the study of insect circadian activity under natural conditions.PLoS biology · 2022Article
- Coordination of siderophore gene expression among clonal cells of the bacterium Pseudomonas aeruginosa.Communications biology · 2022Article
- Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior.PLoS biology · 2021Article
- Applications of cosinor rhythmometry in pharmacology.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under natural conditions, many aspects of the abiotic and biotic environment vary with time of day, season or even era, while these conditions are typically kept constant in laboratory settings. The timing information contained within the environment serves as critical timing cues for the internal biological timing system, but how this system drives daily rhythms in behaviour and physiology may also depend on the internal state of the animal. The disparity between timing of these cues in natural and laboratory conditions can result in substantial differences in the scheduling of behaviour and physiology under these conditions. In nature, temporal coordination of biological processes is critical to maximize fitness because they optimize the balance between reproduction, foraging and predation risk. Here we focus on the role of peripheral circadian clocks, and the rhythms that they drive, in enabling adaptive phenotypes. We discuss how reproduction, endocrine activity and metabolism interact with peripheral clocks, and outline the complex phenotypes arising from changes in this system. We conclude that peripheral timing is critical to adaptive plasticity of circadian organization in the field, and that we must abandon standard laboratory conditions to understand the mechanisms that underlie this plasticity which maximizes fitness under natural conditions.This article is part of the themed issue 'Wild clocks: integrating chronobiology and ecology to understand timekeeping in free-living animals'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.