ArticleMolecular and cellular biology2017
The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation.
Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- TACI regulates marginal zone B cell development.The Journal of experimental medicine · 2026Article
- The transcription repressor Bach2 is required for maintaining the B-1 cell population by regulating self-renewal.Frontiers in immunology · 2025Article
- Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development.Nature immunology · 2024Article
- Review
- Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions.The EMBO journal · 2024Article
- B cell memory: from generation to reactivation: a multipronged defense wall against pathogens.Cell death discovery · 2024Review
- Regulation of the immune system by the insulin receptor in health and disease.Frontiers in endocrinology · 2023Review
- The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.eLife · 2022Article
- Article
- Protocol forSTAR protocols · 2021Article
- Transcriptional regulation of memory B cell differentiation.Nature reviews. Immunology · 2021Review
- Potent antitumour of the mTORC1/2 dual inhibitor AZD2014 in docetaxel-sensitive and docetaxel-resistant castration-resistant prostate cancer cells.Journal of cellular and molecular medicine · 2021Article
- Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo.BMC cancer · 2020Article
- IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium.Journal of molecular and cellular cardiology · 2020Article
- Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.Nature communications · 2020Article
- Transcriptomic analysis of early B-cell development in the chicken embryo.Poultry science · 2019Article
- Molecular regulation of peripheral B cells and their progeny in immunity.Genes & development · 2019Review
- Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation.The Journal of experimental medicine · 2018Article
- TOR signaling in plants: conservation and innovation.Development (Cambridge, England) · 2018Review
- Zinc finger-IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell.Blood advances · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor Bach2 regulates both acquired and innate immunity at multiple steps, including antibody class switching and regulatory T cell development in activated B and T cells, respectively. However, little is known about the molecular mechanisms of Bach2 regulation in response to signaling of cytokines and antigen. We show here that mammalian target of rapamycin (mTOR) controls Bach2 along B cell differentiation with two distinct mechanisms in pre-B cells. First, mTOR complex 1 (mTORC1) inhibited accumulation of Bach2 protein in nuclei and reduced its stability. Second, mTOR complex 2 (mTORC2) inhibited FoxO1 to reduce
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.