Evidence map›Paper›PMID 28993455›Full record

ArticleInfection and immunity2017

Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte.

Taslima T Lina, Tian Luo, Thangam-Sudha Velayutham, Seema Das, Jere W McBride

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Cell signaling inFrontiers in cellular and infection microbiology · 2025
    Review
  4. Article
  5. Infection and immunity · 2023
    Article
  6. Type 1 secretion system and effectors in Rickettsiales.Frontiers in cellular and infection microbiology · 2023
    Review
  7. Establishing the intracellular niche of obligate intracellular vacuolar pathogens.Frontiers in cellular and infection microbiology · 2023
    Review
  8. Frontiers in cellular and infection microbiology · 2023
    Review
  9. mBio · 2022
    Article
  10. Apoptosis and Autophagy: Current Understanding in Tick-Pathogen Interactions.Frontiers in cellular and infection microbiology · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Frontiers in immunology · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Taslima T LinaDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA Taslima.Lina@fda.hhs.gov jemcbrid@utmb.edu.
Tian LuoDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Thangam-Sudha VelayuthamDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Seema DasDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Jere W McBrideDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA Taslima.Lina@fda.hhs.gov jemcbrid@utmb.edu.ORCID http://orcid.org/0000-0003-3335-1539
The University of Texas Medical Branch at Galveston · US

Funding

Ehrlichia T1S Effector Regulation of Host Gene TranscriptionR01AI106859 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MCBRIDE, JERE W · 2014 to 2017
$1.5M
Notch signaling and functional relevance during Ehrlichia chaffeensis infectionR21AI123610 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MCBRIDE, JERE W · 2017 to 2018
$420k
Wnt signaling during Ehrlichia infectionR21AI126144 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MCBRIDE, JERE W · 2016 to 2017
$420k
NIAID NIH HHS R01 AI106859NIAID NIH HHS R21 AI123610NIAID NIH HHS R21 AI126144
6 · The paper itself

Abstract

In multicellular organisms, autophagy is induced as an innate defense mechanism. Notably, the obligate intracellular bacterium

Indexed as

Host-Pathogen InteractionsImmune EvasionWnt Signaling PathwayAutophagyEhrlichia chaffeensisHumansMonocytesPhagocytosisPhosphatidylinositol 3-KinaseTHP-1 CellsTOR Serine-Threonine KinasesMTOR protein, humanPhosphatidylinositol 3-KinaseTOR Serine-Threonine KinasesautophagyEhrlichia chaffeensislysosomeWnt

Identifiers

PMID28993455
PMCPMC5695117
OpenAlexW2762001618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.