Evidence map›Paper›PMID 28993435›Full record

ArticleEndocrine connections2017

Impact of intercurrent illness on calcium homeostasis in children with hypoparathyroidism: a case series.

A Chinoy, M Skae, A Babiker, D Kendall, M Z Mughal, R Padidela

Open access · goldAbstract read
In one paragraph

Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Expanding the Phenotypic Spectrum of Kenny-Caffey Syndrome.The Journal of clinical endocrinology and metabolism · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Management of Hypoparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  7. Review
  8. A child with tetany, convulsions, and nephrocalcinosis: Answers.Pediatric nephrology (Berlin, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

A ChinoyRoyal Manchester Children's HospitalManchester, UK.
M SkaeRoyal Manchester Children's HospitalManchester, UK.
A BabikerKing Abdullah Specialized Children's HospitalRiyadh, Saudi Arabia.
D KendallRoyal Preston HospitalPreston, UK.
M Z MughalRoyal Manchester Children's HospitalManchester, UK.
R PadidelaRoyal Manchester Children's HospitalManchester, UK Raja.Padidela@cmft.nhs.uk.
Royal Manchester Children's Hospital · GBRoyal Preston Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoparathyroidism is characterised by hypocalcaemia, and standard management is with an active vitamin D analogue and adequate oral calcium intake (dietary and/or supplements). Little is described in the literature about the impact of intercurrent illnesses on calcium homeostasis in children with hypoparathyroidism.

methodsWe describe three children with hypoparathyroidism in whom intercurrent illnesses led to hypocalcaemia and escalation of treatment with alfacalcidol (1-hydroxycholecalciferol) and calcium supplements.

resultsThree infants managed with standard treatment for hypoparathyroidism (two with homozygous mutations in

conclusionIntercurrent illness may precipitate symptomatic hypocalcaemia in children with hypoparathyroidism, necessitating increase in dosages of alfacalcidol and calcium supplements. Close monitoring is required on resolution of the intercurrent illness, with timely reduction of dosages of active analogues of vitamin D and calcium supplements to prevent hypercalcaemia, hypercalciuria and nephrocalcinosis.

Indexed as

alfacalcidolhypocalcaemiahypoparathyroidismintercurrent illness

Identifiers

PMID28993435
PMCPMC5633055
OpenAlexW2762139939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.