ArticleCancer research2017
Open access · bronzeAbstract read
In one paragraph
Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation.Nature communications · 2026Article
- Association between NAT10 gene rs8187 G > A polymorphism and Wilms tumor susceptibility in Chinese Han children: a five-center case-control study.BMC cancer · 2025Article
- Acetyltransferase NAT10 inhibits T-cell immunity and promotes nasopharyngeal carcinoma progression through DDX5/HMGB1 axis.Journal for immunotherapy of cancer · 2025Article
- Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model.Clinical science (London, England : 1979) · 2024Article
- Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.Oncogene · 2024Review
- N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.Nature communications · 2024Article
- NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA.Cancer biology & therapy · 2023Article
- Article
- Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression.Journal of experimental & clinical cancer research : CR · 2023Article
- Advances in transposable elements: from mechanisms to applications in mammalian genomics.Frontiers in genetics · 2023Review
- NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation.Cell death and differentiation · 2022Article
- Site-Specific Synthesis ofJournal of the American Chemical Society · 2022Article
- ac4C acetylation of RUNX2 catalyzed by NAT10 spurs osteogenesis of BMSCs and prevents ovariectomy-induced bone loss.Molecular therapy. Nucleic acids · 2021Article
- Exploring liver cancer biology through functional genetic screens.Nature reviews. Gastroenterology & hepatology · 2021Review
- Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions.Molecular cancer research : MCR · 2021Article
- Quantitative nucleotide resolution profiling of RNA cytidine acetylation by ac4C-seq.Nature protocols · 2021Article
- Prognostic and Immunological Role of mRNA ac4C Regulator NAT10 in Pan-Cancer: New Territory for Cancer Research?Frontiers in oncology · 2021Article
- In vivo functional screening for systems-level integrative cancer genomics.Nature reviews. Cancer · 2020Review
- Article
- Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer.Nucleic acids research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 1 institution in 1 country.
Barbara R TschidaDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Nuri A TemizDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Timothy P KukaDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Lindsey A LeeDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Jesse D RiordanPacific Northwest Research Institute, Seattle, Washington.
Carlos A TierrablancaDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Robert HullsiekDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Sandra WagnerDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Wendy A HudsonDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Michael A LindenDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
Khalid AminDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
Pauline J BeckmannDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Rachel A HeuerDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Aaron L SarverDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Ju Dong YangDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Lewis R RobertsDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Joseph H NadeauPacific Northwest Research Institute, Seattle, Washington.
Adam J DupuyDepartment of Anatomy and Cell Biology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Vincent W KengThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China. larga002@umn.edu vincent.keng@polyu.edu.hk.
David A LargaespadaDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota. larga002@umn.edu vincent.keng@polyu.edu.hk.
Pacific Northwest Diabetes Research Institute · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MMinnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2MSleeping Beauty for uncovering cancer genes in miceR01CA113636 · NCI · UNIVERSITY OF MINNESOTA · PI LARGAESPADA, DAVID ANDREW · 2006 to 2016
$2.5MA Genetic Screen for HCC GenesR01CA132962 · NCI · UNIVERSITY OF MINNESOTA · PI DUPUY, ADAM J., LARGAESPADA, DAVID ANDREW · 2010 to 2014
$1.5MBioinformatics approaches to solve the "Missing Driver" problem in solid tumorsR50CA211249 · NCI · UNIVERSITY OF MINNESOTA · PI SARVER, AARON L · 2016 to 2020
$565kMechanisms of differential susceptibility to nonalcoholic fatty liver diseaseF32DK109651 · NIDDK · PACIFIC NORTHWEST RESEARCH INSTITUTE · PI RIORDAN, JESSE DANIEL · 2016 to 2018
$124kNCI NIH HHS R01 CA113636NCI NIH HHS R01 CA132962NCI NIH HHS R50 CA211249NIAID NIH HHS T32 AI083196NIDDK NIH HHS F32 DK109651
Abstract
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using
Indexed as
AnimalsCarcinoma, HepatocellularCell Transformation, NeoplasticCyclic AMP-Dependent Protein KinasesDNA Transposable ElementsFatty LiverFemaleHumansLiverLiver NeoplasmsMaleMiceMice, Inbred C57BLMice, KnockoutMutagenesisMutagenesis, InsertionalCyclic AMP-Dependent Protein KinasesDNA Transposable ElementsNAT10 protein, humanN-Terminal Acetyltransferase EN-Terminal Acetyltransferasessleeping beauty transposase, humanTransposases
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.