Evidence map›Paper›PMID 28993402›Full record

ArticleCirculation2018

Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Diagnosing and Ranking Its Causes Using Personalized O

Nicholas E Houstis, Aaron S Eisman, Paul P Pappagianopoulos, Luke Wooster, Cole S Bailey, Peter D Wagner, Gregory D Lewis

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 157 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 6 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04945707 phase4active not recruitingnot on this mapstarted 2021, after this paper: background citation

A Double-blind,Randomized, Placebo-controlled Study to Assess Exercise Tolerance After Iron Repletion With Ferric Derisomaltose (Monoferric®) IV Compared to Placebo in Heart Failure With Preserved Ejection Fraction and With Iron Deficiency.

TypeinterventionalSponsorMassachusetts General HospitalRan2021 to 2026Enrolled65ConditionsIron-deficiency, Heart Failure With Preserved Ejection FractionArmsFerric Derisomaltose 1000 Mg in 100 mL INTRAVENOUS SOLUTION [Monoferric], Placebo
NCT06650995 narecruitingnot on this mapstarted 2026, after this paper: background citation

AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure

TypeinterventionalSponsorTechnical University of MunichRan2026 to 2027Enrolled40ConditionsHFpEF - Heart Failure With Preserved Ejection Fraction, Atrial FibrillationArmsExercise training
NCT07202000 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Double-blind, Prospective, Randomized, Placebo-controlled Trial to Assess if Activin Ligand-trap Biological Therapy Can Improve Exercise Capacity and Cognitive Function in Heart Failure With Preserved Ejection Fraction Compared to Placebo.

TypeinterventionalSponsorMassachusetts General HospitalRan2026 to 2027Enrolled48ConditionsHeart Failure With Preserved Ejection FractionArmsActivin ligand-trap biological therapy, Placebo, Normal Saline
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 6 syntheses or guidelines pooled it, 251 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Highlights in heart failure.ESC heart failure · 2019
    Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Peak OESC heart failure · 2022
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Review
  15. The Intersection of Heart Failure with Preserved Ejection Fraction and CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  16. Effects of sympathomodulation on pulse wave properties in heart failure with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Article

97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nicholas E HoustisCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (N.E.H., A.S.E., P.P.P., L.W., C.S.B., G.D.L.).
Aaron S EismanCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (N.E.H., A.S.E., P.P.P., L.W., C.S.B., G.D.L.).
Paul P PappagianopoulosCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (N.E.H., A.S.E., P.P.P., L.W., C.S.B., G.D.L.).
Luke WoosterCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (N.E.H., A.S.E., P.P.P., L.W., C.S.B., G.D.L.).
Cole S BaileyCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (N.E.H., A.S.E., P.P.P., L.W., C.S.B., G.D.L.).
Peter D WagnerSchool of Medicine, University of California, San Diego (P.D.W.).
Gregory D LewisCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (N.E.H., A.S.E., P.P.P., L.W., C.S.B., G.D.L.) glewis@partners.org.
Massachusetts General Hospital · US

Funding

Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7M
NCATS NIH HHS KL2 TR001100NHLBI NIH HHS R01 HL131029
6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) is a common syndrome with a pressing shortage of therapies. Exercise intolerance is a cardinal symptom of HFpEF, yet its pathophysiology remains uncertain.

methodsWe investigated the mechanism of exercise intolerance in 134 patients referred for cardiopulmonary exercise testing: 79 with HFpEF and 55 controls. We performed cardiopulmonary exercise testing with invasive monitoring to measure hemodynamics, blood gases, and gas exchange during exercise. We used these measurements to quantify 6 steps of oxygen transport and utilization (the O

resultsPeak Vo

conclusionsSystematic analysis of the O

Indexed as

Exercise TestExercise ToleranceOxygen ConsumptionStroke VolumeVentricular Function, LeftAgedComorbidityFemaleHealth StatusHeart FailureHumansMaleMiddle AgedMuscle, SkeletalPredictive Value of TestsPrognosiscardiac outputcomorbiditydiagnosisdiffusionmicrocirculationsystems biologytaxonomy

Identifiers

PMID28993402
PMCPMC5760316
OpenAlexW2762427866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.