ArticleBMJ open2017
Impacts of undetected and inadequately treated hypertension on incident stroke in China.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pooled incidence and case-fatality of acute stroke in Mainland China, Hong Kong, and Macao: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Trial
- Knowledge, attitude, and practices of hypertensive patients toward stroke prevention among rural population in NCR, India: A cross-sectional survey.Journal of family medicine and primary care · 2025Article
- Untreated and uncontrolled hypertension in Japanese patients with spontaneous intracerebral hemorrhage.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Decomposing the rural-urban gap in the prevalence of undiagnosed, untreated and under-treated hypertension among older adults in India.BMC public health · 2022Article
- Article
- Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan.International journal of hypertension · 2022Article
- Correlation between Stroke Risk and Systolic Blood Pressure in Patients over 50 Years with Uncontrolled Hypertension: Results from the SYSTUP-India Study.Cardiovascular therapeutics · 2021Observational
- Article
- Tele-ECG consulting and outcomes on primary care patients in a low-to-middle income population: the first experience from Makassar telemedicine program, Indonesia.BMC family practice · 2020Article
- Development and validation of a 2-year new-onset stroke risk prediction model for people over age 45 in China.Medicine · 2020Article
- Association between socioeconomic status and incident stroke in China.Journal of epidemiology and community health · 2020Article
- The population attributable risk and clustering of stroke risk factors in different economical regions of China.Medicine · 2020Article
- Associations of body fat and skeletal muscle with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Association of CALM1 rs3179089 Polymorphism with Ischemic Stroke in Chinese Han Population.Neuromolecular medicine · 2018Article
- Awareness and adherence to primary and primordial preventive measures among family members of patients with myocardial infarction-the unmet need for a "Preventive Clinic".Indian heart journalArticle
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesChina carries the greatest burden of stroke given its largest volume of people with hypertension. This study assessed the impacts of suboptimal controls of hypertension on incident stroke and projected the number of patients with stroke saved after the control of blood pressure improved in population.
settingAnhui, China.
participantsWe examined data from the Anhui cohort of 2001-2011, consisting of 3336 participants aged ≥60 years who were randomly recruited from the urban and rural Anhui. 2852 participants (89.2%) had hypertensive status measured and no stroke at baseline, and were followed up until 2011 in three surveys using a standard method of interview.
resultsAt baseline, 1646 participants (57.7%) were identified to have hypertension, among whom 912 (55.4%) were previously undetected, 115 (7.0%) detected but not treated, 452 (27.5%) treated but not controlled and only 127 (7.7%) controlled. During the 10-year follow-up, 211 incident stroke cases (12.8/1000 person-years) occurred. Compared with normotensive individuals at baseline, multivariate adjusted HR for having stroke increased in those with undetected hypertension by 1.63 (95%CI 1.15 to 2.32), untreated by 2.21 (1.26-3.85) and uncontrolled hypertension by 3.34 (2.28-4.88), but did not differ from those with controlled hypertension (1.34; 0.60-2.99). Based on a two-fold increase in the detection and management of current levels of hypertension and algorithms on the current situation in China, approximately 250 000 incident stroke cases could be prevented annually.
conclusionsIn China, hypertension is frequently undetected or inadequately treated. With appropriate management of hypertension, a substantial number of people could be saved form stroke.
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