Evidence map›Paper›PMID 28993326›Full record

ArticleAntimicrobial agents and chemotherapy2017

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum.

Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya J I Fowkes, Leann Tilley, Julie A Simpson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Artemisinin-resistant malaria.Clinical microbiology reviews · 2024
    Review
  2. Article
  3. Article
  4. Development and Validation of anAntimicrobial agents and chemotherapy · 2021
    Article
  5. Antimicrobial agents and chemotherapy · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pengxing CaoSchool of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.
Nectarios KlonisDepartment of Biochemistry and Molecular Biology and Australian Research Council Centre of Excellence for Coherent X-Ray Science, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
Sophie ZaloumisCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Con DogovskiDepartment of Biochemistry and Molecular Biology and Australian Research Council Centre of Excellence for Coherent X-Ray Science, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
Stanley C XieDepartment of Biochemistry and Molecular Biology and Australian Research Council Centre of Excellence for Coherent X-Ray Science, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
Sompob SaralambaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok, Thailand.
Lisa J WhiteMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok, Thailand.
Freya J I FowkesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Leann TilleyDepartment of Biochemistry and Molecular Biology and Australian Research Council Centre of Excellence for Coherent X-Ray Science, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
Julie A SimpsonCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
James M McCawSchool of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia jamesm@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light of developing resistance to partner drugs. Improving our understanding of how artemisinin-based drugs act and how resistance manifests is essential for the optimization of dosing regimens and the development of strategies to prolong the life span of current first-line treatment options. Recent short-drug-pulse

Indexed as

AntimalarialsArtemisininsDrug ResistanceHumansMalaria, FalciparumModels, BiologicalPlasmodium falciparumStress, PhysiologicalAntimalarialsArtemisininsartemisinin actiondrug exposure timedynamic modelPlasmodium falciparum

Identifiers

PMID28993326
PMCPMC5700357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.