Evidence map›Paper›PMID 28993242›Full record

ArticleNeurobiology of disease2018

A distinct microRNA expression profile is associated with α[

Shruti Bagla, Daniela Cukovic, Eishi Asano, Sandeep Sood, Aimee Luat, Harry T Chugani, Diane C Chugani, Alan A Dombkowski

Open access · greenAbstract read
In one paragraph

Article in Neurobiology of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Frontiers in physiology · 2021
    Article
  12. Article
  13. Review
  14. TLR7 activation in epilepsy of tuberous sclerosis complex.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
    Article
  15. Article
  16. Neuroinflammatory Nexus of Pediatric Epilepsy.Journal of pediatric epilepsy · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shruti BaglaDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
Daniela CukovicDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
Eishi AsanoDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
Sandeep SoodDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA.
Aimee LuatDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
Harry T ChuganiDepartment of Neurology, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
Diane C ChuganiResearch Department, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA; Communication Sciences and Disorders Department, College of Health Sciences, University of Delaware, Newark, DE, USA.
Alan A DombkowskiDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: domski@wayne.edu.
Wayne State University · USAlfred I. duPont Hospital for Children · US

Funding

Identifying Epileptogenic Tubers in TSCR01NS064989 · NINDS · WAYNE STATE UNIVERSITY · PI CHUGANI, HARRY · 2010 to 2014
$1.6M
Imaging tryptophan metabolism in children with epilepsyR01NS045151 · NINDS · WAYNE STATE UNIVERSITY · PI CHUGANI, DIANE C · 2004 to 2007
$1.2M
The Role of microRNAs in Epilepsy of Tuberous Sclerosis ComplexR01NS079429 · NINDS · WAYNE STATE UNIVERSITY · PI DOMBKOWSKI, ALAN A · 2014 to 2016
$998k
NINDS NIH HHS R01 NS045151NINDS NIH HHS R01 NS064989NINDS NIH HHS R01 NS079429
6 · The paper itself

Abstract

Tuberous sclerosis complex (TSC) is characterized by hamartomatous lesions in various organs and arises due to mutations in the TSC1 or TSC2 genes. TSC mutations lead to a range of neurological manifestations including epilepsy, cognitive impairment, autism spectrum disorders (ASD), and brain lesions that include cortical tubers. There is evidence that seizures arise at or near cortical tubers, but it is unknown why some tubers are epileptogenic while others are not. We have previously reported increased tryptophan metabolism measured with α[

Indexed as

Positron-Emission TomographyChildChild, PreschoolFemaleGene ExpressionGene Expression ProfilingHumansInfantK Cl- CotransportersMaleMicroRNAsSeizuresSymportersTryptophanTuberous Sclerosisalpha-methyltryptophanK Cl- CotransportersMicroRNAsMIR223, humanMIRN142 microRNA, humanSLC12A5 protein, humanSymportersTryptophanEpilepsyGene expressionmicroRNAPositron emission tomographySeizureTryptophanTuberous sclerosis complexα[(11)C]-methyl-L-tryptophan

Identifiers

PMID28993242
PMCPMC6070303
OpenAlexW2761105091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.