Evidence map›Paper›PMID 28992939›Full record

ArticleAtherosclerosis2017

Kidney function, bone-mineral metabolism markers, and future risk of peripheral artery disease.

Chao Yang, Lucia Kwak, Shoshana H Ballew, Pranav S Garimella, Bernard G Jaar, Aaron R Folsom, Gerardo Heiss, Elizabeth Selvin, Pamela L Lutsey, Josef Coresh and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Chao YangJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Lucia KwakJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Shoshana H BallewJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Pranav S GarimellaUniversity of California at San Diego, San Diego, CA, USA.
Bernard G JaarJohns Hopkins School of Medicine, Baltimore, MD, USA.
Aaron R FolsomUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
Gerardo HeissUniversity of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, USA.
Elizabeth SelvinJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Johns Hopkins School of Medicine, Baltimore, MD, USA.
Pamela L LutseyUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
Josef CoreshJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kunihiro MatsushitaJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: kmatsus5@jhu.edu.
Johns Hopkins University · USUniversity of Minnesota · USUniversity of California San Diego · USUniversity of North Carolina at Chapel Hill · US

Funding

Diabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4M
Research and Mentoring in the Clinical Epidemiology of Type 2 DiabetesK24DK106414 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2015 to 2019
$654k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNIDDK NIH HHS K24 DK106414NIDDK NIH HHS R01 DK089174
6 · The paper itself

Abstract

BACKGROUND AND

aimsReduced kidney function is a risk factor for lower-extremity peripheral artery disease (PAD). However, the associations of novel filtration markers with PAD are yet to be quantified. Moreover, little is known on whether bone-mineral metabolism (BMM) markers are related to incident PAD beyond kidney function.

methodsUsing data from 12,472 participants at baseline (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) study, we comprehensively quantified the associations of kidney related markers with incident PAD (defined as hospitalizations with diagnosis of lower-extremity atherosclerosis, revascularization, or amputation). Kidney related markers of interest included estimated glomerular filtration rate (eGFR) (based on creatinine, cystatin C, and both), cystatin C, beta-2 microglobulin (B2M), and BMM markers (serum fibroblast growth factor 23, parathyroid hormone, calcium, and phosphorus).

resultsDuring a median follow-up of 21 years, 471 participants developed incident PAD. Low eGFR was significantly associated with future PAD risk, with slightly stronger relationship when cystatin C was used (adjusted hazard ratio [HR] 6.3-8.3 for eGFR <30 and 2.4-3.5 for eGFR 30-59 vs. eGFR ≥90 mL/min/1.73 m

conclusionsKidney dysfunction was independently associated with future PAD risk, particularly when assessed with cystatin C and B2M. Among the BMM markers tested, phosphorus was most robustly associated with incident PAD beyond kidney function. Our results suggest the potential usefulness of novel filtration markers for PAD risk assessment and the possible role of phosphorus in the pathophysiology of PAD.

Indexed as

Bone DensityKidney Function Testsbeta 2-MicroglobulinBiomarkersBody Mass IndexBone and BonesCalciumCreatinineCystatin CFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsFollow-Up StudiesGlomerular Filtration RateHospitalizationHumansbeta 2-MicroglobulinBiomarkersCalciumCreatinineCystatin CFibroblast Growth Factor-23Fibroblast Growth FactorsParathyroid HormonePhosphorusBone-mineral metabolism markersKidney markersPeripheral artery diseaseProspective cohort study

Identifiers

PMID28992939
PMCPMC5705382
OpenAlexW2760721940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.