Evidence map›Paper›PMID 28992833›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2017

Non-24-Hour Sleep-Wake Rhythm Disorder and Melatonin Secretion Impairment in a Patient With Pineal Cyst.

Lorenzo Ferri, Marco Filardi, Monica Moresco, Fabio Pizza, Stefano Vandi, Elena Antelmi, Francesco Toni, Mino Zucchelli, Giulia Pierangeli, Giuseppe Plazzi

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Pineal Cysts: Clinical Insights and Management Strategies.Advances and technical standards in neurosurgery · 2026
    Review
  4. The Pinealoprive Syndrome: Myth or Reality?Advances and technical standards in neurosurgery · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Sleep deprivation therapy to reset the circadian pacemaker in a non-24-hour sleep-wake disorder: a case report.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
  9. Article
  10. Article
  11. Non-24-Hour Sleep-Wake Disorder in Sighted Patients: Dealing With an Orphan Disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lorenzo FerriDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Marco FilardiDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Monica MorescoDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Fabio PizzaDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Stefano VandiDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Elena AntelmiDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Francesco ToniIRCCS Institute of Neurological Science of Bologna, Division of Neuroradiology, Bellaria Hospital, Bologna, Italy.
Mino ZucchelliIRCCS Institute of Neurological Science Bologna, Pediatric Neurosurgery, Bellaria Hospital, Bologna, Italy.
Giulia PierangeliDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Giuseppe PlazziDIBINEM - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
University of Bologna · ITInstitute of Neurological Sciences · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractWe report the case of a 14-year-old girl with a wide non-compressive pineal cyst, associated with the inability to control her sleep-wake schedule. Actigraphic monitoring showed a 24-hour free-running disorder (tau 26.96 hours). A 24-hour serum melatonin curve assay, with concomitant video-polysomnographic and body-core temperature monitoring, was performed. Melatonin curve showed a blunted nocturnal peak, lower total quantity of melatonin, and prolonged melatonin secretion in the morning, with normal temperature profile and sleep parameters. Treatment with melatonin up to 14 mg at bedtime was initiated with complete realignment of the sleep-wake rhythm (tau 23.93 hours). The role of the pineal cyst in the aforementioned alteration of melatonin secretion and free-running disorder remains controversial, but our case supports the utility of monitoring sleep/wake, temperature, and melatonin rhythms in the diagnostic work-up of pineal cysts associated with free-running disorder.

Indexed as

AdolescentCentral Nervous System DepressantsCystsFemaleHumansMelatoninPineal GlandSleep Disorders, Circadian RhythmTreatment OutcomeCentral Nervous System DepressantsMelatoninactigraphybody-core temperaturefree-running disordermelatoninpineal cyst

Identifiers

PMID28992833
PMCPMC5656486
OpenAlexW2770689241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.