Evidence map›Paper›PMID 28992615›Full record

ReviewInternational archives of allergy and immunology2017

Contributions and Future Directions for Structural Biology in the Study of Allergens.

Geoffrey A Mueller

Abstract readReview
In one paragraph

Review in International archives of allergy and immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Design of an Ara h 2 hypoallergen from conformational epitopes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024
    Article
  4. An allergenic plant calmodulin fromFrontiers in immunology · 2022
    Article
  5. Mapping Human Monoclonal IgE Epitopes on the Major Dust Mite Allergen Der p 2.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  6. Review
  7. Article
  8. Review
  9. Microarray Immunodiagnostics for Aeroallergens.Current allergy and asthma reports · 2019
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Geoffrey A MuellerDepartment of Health and Human Services, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Funding

Structural and Functional Characterization of AllergensZIAES102906 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MUELLER, GEOFFREY · 2010 to 2025
$10.0M
Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIA ES102906
6 · The paper itself

Abstract

Allergy is defined as an inappropriate immune response to something normally considered harmless. The symptomatic immune response is driven by IgE antibodies directed against allergens. The study of allergens has contributed significantly to our understanding of allergic disease in 3 main areas. First, identifying allergens as the cause of symptoms and developing allergen standards has led to many advances in exposure assessment and patient diagnostics. Second, a biochemical understanding of allergens has suggested a number of hypotheses related to the mechanisms of allergic sensitization. And finally, studies of allergen-antibody interactions have contributed to understanding the cross-reactivity of allergens, mapping patient epitopes, and the development of hypoallergens. In this review, a few select cases are highlighted where structural biology, in particular, has contributed significantly to allergen research and provided new avenues for investigation.

Indexed as

ImmunizationAllergensAntigen-Antibody ReactionsCross ReactionsHumansHypersensitivityImmunoglobulin EProtein Structure, TertiaryAllergensImmunoglobulin EAllergensSensitizationStandardizationStructural biology

Identifiers

PMID28992615
PMCPMC5693727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.