Evidence map›Paper›PMID 28992382›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2018

Arterial Inflammation Detected With

Laura Geraldino-Pardilla, Afshin Zartoshti, Ayse Bag Ozbek, Jon T Giles, Richard Weinberg, Mona Kinkhabwala, Sabahat Bokhari, Joan M Bathon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Enhanced vascular inflammation in patients with advanced prostate cancer receiving hormone therapy.European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Frontiers in medicine · 2022
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laura Geraldino-PardillaColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
Afshin ZartoshtiColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
Ayse Bag OzbekColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
Jon T GilesColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
Richard WeinbergColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
Mona KinkhabwalaColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
Sabahat BokhariColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
Joan M BathonColumbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
New York Hospital Queens · USNewYork–Presbyterian Hospital · USColumbia University · US

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Inflammation and Cardiovascular Disease in Rheumatoid ArthritisR01AR050026 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI BATHON, JOAN MARIE · 2004 to 2022
$9.7M
Inflammation and Cardiovascular Disease in RAR55AR050026 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI BATHON, JOAN MARIE · 2003 to 2003
$100k
NCATS NIH HHS UL1 TR000040NIAMS NIH HHS R01 AR050026NIAMS NIH HHS R55 AR050026
6 · The paper itself

Abstract

objectiveIn addition to traditional risk factors, excess cardiovascular disease (CVD) in rheumatoid arthritis (RA) is attributed to enhanced vascular and/or systemic inflammation. In several small studies using

methodsRA patients underwent cardiac FDG-PET/CT, with aortic inflammation assessed by quantification of FDG uptake in the ascending aorta, calculated as the mean and maximum (max) standardized uptake value (SUV) of the entire ascending aorta and of its most diseased segment (SUV MDS). Univariate and multivariable regression models were constructed to model the associations of patient characteristics with aortic FDG uptake.

resultsNinety-one RA patients were scanned. In multivariable models, in addition to the independent associations of hypertension and body mass index with increased aortic FDG uptake, the prevalence of rheumatoid nodules correlated with the SUV mean and SUV MDS mean measures, while anti-cyclic citrullinated peptide (anti-CCP) antibodies correlated inversely with these measures and with the SUV max and SUV MDS max (P < 0.05). A significant association of RA disease activity with aortic FDG uptake was observed but was restricted to anti-CCP seropositivity.

conclusionTraditional CV risk factors and RA disease characteristics (rheumatoid nodules and the Disease Activity Score in 28 joints using the C-reactive protein level in anti-CCP antibody-positive individuals) were independently associated with ascending aortic FDG uptake in RA patients without clinical CVD.

Indexed as

AdultAgedAortaArteritisArthritis, RheumatoidCross-Sectional StudiesFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron-Emission TomographyFluorodeoxyglucose F18

Identifiers

PMID28992382
PMCPMC5745261
OpenAlexW2762238970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.