ArticleJournal of radiation research2017
Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation.
Article in Journal of radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Organ-specific modulation of antioxidant functions by combined voluntary exercise and radon inhalation in mice.Journal of clinical biochemistry and nutrition · 2026Article
- Enhancement of antioxidant function in various organs in mice using combined thermal and radon inhalation treatment.Journal of radiation research · 2026Article
- Characterization of Archaea membrane lipids in radioactive springs using shotgun lipidomics.Folia microbiologica · 2025Article
- Assessment of Threshold Dose of Thoron Inhalation and Its Biological Effects by Mimicking the Radiation Doses in Monazite Placer Deposits Corresponding to the Normal, Medium and Very High Natural Background Radiation Areas.Biological trace element research · 2023Article
- Chronic Home Radon Exposure Is Associated with Higher Inflammatory Biomarker Concentrations in Children and Adolescents.International journal of environmental research and public health · 2022Article
- Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice.Journal of radiation research · 2022Article
- Changes in Sulfur Metabolism in Mouse Brains following Radon Inhalation.International journal of environmental research and public health · 2022Article
- Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy.Journal of clinical biochemistry and nutrition · 2022Article
- Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions.Journal of radiation research · 2021Article
- Evaluation of the redox state in mouse organs following radon inhalation.Journal of radiation research · 2021Article
- Radon Exposure-Therapeutic Effect and Cancer Risk.International journal of molecular sciences · 2020Review
- Comparison of antioxidative effects between radon and thoron inhalation in mouse organs.Radiation and environmental biophysics · 2020Article
- Prospects for Radiopharmaceuticals as Effective and Safe Therapeutics in Oncology and Challenges of Tumor Resistance to Radiotherapy.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 for 24 h. After inhalation, brains were removed quickly for analysis. Radon inhalation increased the manganese (Mn)-SOD level and mitochondrial SOD activity. However, the differences were not significant. There were no changes in the Cu/Zn-SOD level or cytosolic SOD activity. Radon inhalation increased the brain nuclear factor (NF)-κB content, which regulates the induction of Mn-SOD, in the nuclear and cytosolic compartments. The level of inhibitor of nuclear factor κB kinase subunit β (IKK-β), which activates NF-κB, was slightly increased by radon inhalation. The expression of cytoplasmic ataxia-telangiectasia mutated kinase in mice inhaling radon at 500 Bq/m3 was 50% higher than in control mice. In addition, NF-κB-inducing kinase was slightly increased after inhaling radon at 2000 Bq/m3. These findings suggest that radon inhalation might induce Mn-SOD protein via NF-κB activation that occurs in response to DNA damage and oxidative stress.
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