ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2017
Co-adaption of tRNA gene copy number and amino acid usage influences translation rates in three life domains.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 31 citations in OpenAlex.
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- Evidence for Non-optimal Codon Choice in Highly Transcribed Sex-Biased Genes of Drosophila melanogaster.Genome biology and evolution · 2026Article
- Regulation of tRNA expression during the social cycle of the amoeba Dictyostelium discoideum.BMC molecular and cell biology · 2026Article
- Evolution of Translational Machinery in Fast- and Slow-Growing Bacteria.Microorganisms · 2026Article
- Clindamycin susceptibility and virulence characterization ofFrontiers in microbiology · 2026Article
- Comprehensive Analysis of Mitochondrial Genomic Characteristics and Phylogenetic Analysis of the Plant GenusBiology · 2025Article
- Article
- Differential Selection for Translation Efficiency Shapes Translation Machineries in Bacterial Species.Microorganisms · 2024Article
- Variation in Release Factor Abundance Is Not Needed to Explain Trends in Bacterial Stop Codon Usage.Molecular biology and evolution · 2022Article
- Genotype-phenotype correlations within theFrontiers in microbiology · 2022Article
- tRNA copy number and codon usage in the sea cucumber genome provide insights into adaptive translation for saponin biosynthesis.Open biology · 2021Article
- Evolutionary responses to codon usage of horizontally transferred genes inMicrobial genomics · 2021Article
- Adaptation of codon and amino acid use for translational functions in highly expressed cricket genes.BMC genomics · 2021Article
- Comprehensive annotation and characterization of planarian tRNA and tRNA-derived fragments (tRFs).RNA (New York, N.Y.) · 2021Article
- Accurate characterization ofRNA biology · 2021Article
- Comparative Genome Analysis ofJournal of microbiology and biotechnology · 2020Article
- A report on DNA sequence determinants in gene expression.Bioinformation · 2020Article
- Evidence of multifaceted functions of codon usage in translation within the model beetle Tribolium castaneum.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Translational Selection for Speed Is Not Sufficient to Explain Variation in Bacterial Codon Usage Bias.Genome biology and evolution · 2018Article
- The GC Content as a Main Factor Shaping the Amino Acid Usage During Bacterial Evolution Process.Frontiers in microbiology · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although more and more entangled participants of translation process were realized, how they cooperate and co-determine the final translation efficiency still lacks details. Here, we reasoned that the basic translation components, tRNAs and amino acids should be consistent to maximize the efficiency and minimize the cost. We firstly revealed that 310 out of 410 investigated genomes of three domains had significant co-adaptions between the tRNA gene copy numbers and amino acid compositions, indicating that maximum efficiency constitutes ubiquitous selection pressure on protein translation. Furthermore, fast-growing and larger bacteria are found to have significantly better co-adaption and confirmed the effect of this pressure. Within organism, highly expressed proteins and those connected to acute responses have higher co-adaption intensity. Thus, the better co-adaption probably speeds up the growing of cells through accelerating the translation of special proteins. Experimentally, manipulating the tRNA gene copy number to optimize co-adaption between enhanced green fluorescent protein (EGFP) and tRNA gene set of Escherichia coli indeed lifted the translation rate (speed). Finally, as a newly confirmed translation rate regulating mechanism, the co-adaption reflecting translation rate not only deepens our understanding on translation process but also provides an easy and practicable method to improve protein translation rates and productivity.
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