ArticleCritical care medicine2017
Pediatric Sepsis Endotypes Among Adults With Sepsis.
Article in Critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2021Guideline
- Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients.Frontiers in immunology · 2021Trial
- Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients.Cell death & disease · 2026Review
- Human Cytomegalovirus Serostatus Defines Cytokine-Based Predictive Signatures in Sepsis.Pathogens (Basel, Switzerland) · 2026Observational
- Pediatric critical illness endotypes reveal distinct outcomes and immune pathways shared across cause of illness.iScience · 2025Article
- BAYESIAN LEARNING OF CLINICALLY MEANINGFUL SEPSIS PHENOTYPES IN NORTHERN TANZANIA.The annals of applied statistics · 2025Article
- Pediatric Sepsis Phenotype in a Single-Center Cohort Covering 2010-2020: Evolution in Day 1-Day 3 Trajectory and Potential Prognostic Value.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- Sepsis subphenotypes, theragnostics and personalized sepsis care.Intensive care medicine · 2025Review
- Article
- Innate immune response in acute critical illness: a narrative review.Annals of intensive care · 2024Review
- Clinical phenotypes of sepsis: a narrative review.Journal of thoracic disease · 2024Review
- From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.American journal of respiratory and critical care medicine · 2024Review
- Whole blood transcriptomics identifies subclasses of pediatric septic shock.Critical care (London, England) · 2023Article
- Ex Vivo Endotoxin Stimulation of Blood for Predicting Survival in Patients With Sepsis: A Systematic Review.CHEST critical care · 2023Article
- Precision management of acute kidney injury in the intensive care unit: current state of the art.Intensive care medicine · 2023Review
- Clinical Sepsis Phenotypes in Critically Ill Patients.Microorganisms · 2023Review
- The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping andFrontiers in cellular and infection microbiology · 2023Review
- An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.Science translational medicine · 2022Article
- Omics of endothelial cell dysfunction in sepsis.Vascular biology (Bristol, England) · 2022Review
- Pediatric sepsis biomarkers for prognostic and predictive enrichment.Pediatric research · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesRecent transcriptomic studies describe two subgroups of adults with sepsis differentiated by a sepsis response signature. The implied biology and related clinical associations are comparable with recently reported pediatric sepsis endotypes, labeled "A" and "B." We classified adults with sepsis using the pediatric endotyping strategy and the sepsis response signature and determined how endotype assignment, sepsis response signature membership, and age interact with respect to mortality.
designRetrospective analysis of publically available transcriptomic data representing critically ill adults with sepsis from which the sepsis response signature groups were derived and validated.
settingMultiple ICUs. PATIENTS: Adults with sepsis.
interventionsNone. MEASUREMENTS AND MAIN
resultsTranscriptomic data were conormalized into a single dataset yielding 549 unique cases with sepsis response signature assignments. Each subject was assigned to endotype A or B using the expression data for the 100 endotyping genes. There were 163 subjects (30%) assigned to endotype A and 386 to endotype B. There was a weak, positive correlation between endotype assignment and sepsis response signature membership. Mortality rates were similar between patients assigned endotype A and those assigned endotype B. A multivariable logistic regression model fit to endotype assignment, sepsis response signature membership, age, and the respective two-way interactions revealed that endotype A, sepsis response signature 1 membership, older age, and the interactions between them were associated with mortality. Subjects coassigned to endotype A, and sepsis response signature 1 had the highest mortality.
conclusionsCombining the pediatric endotyping strategy with sepsis response signature membership might provide complementary, age-dependent, biological, and prognostic information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.