Evidence map›Paper›PMID 28991406›Full record

ArticleInfluenza and other respiratory viruses2017

Burden of influenza among hospitalized febrile children in Ghana.

Benedikt Hogan, Luise Ammer, Marlow Zimmermann, Tabea Binger, Ralf Krumkamp, Nimako Sarpong, Theresa Rettig, Denise Dekker, Benno Kreuels, Lisa Reigl and 6 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Epidemiology of influenza in Ghana, 2011 to 2019.PLOS global public health · 2022
    Article
  7. Article
  8. Malaria Coinfections in Febrile Pediatric Inpatients: A Hospital-Based Study From Ghana.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  9. Burden of influenza among hospitalized febrile children in Ghana.Influenza and other respiratory viruses · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Benedikt HoganInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.ORCID 0000-0003-0853-4755
Luise AmmerInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.
Marlow ZimmermannInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.
Tabea BingerCollege of Health Sciences, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), KNUST, Kumasi, Ghana.
Ralf KrumkampInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.
Nimako SarpongCollege of Health Sciences, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), KNUST, Kumasi, Ghana.
Theresa RettigDepartment of Child Health, Agogo Presbyterian Hospital, Agogo, Ghana.
Denise DekkerInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.
Benno KreuelsGerman Center for Infection Research (DZIF), Hamburg-Borstel-Lübeck, Germany.
Lisa ReiglInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.
Kennedy G BoahenCollege of Health Sciences, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), KNUST, Kumasi, Ghana.
Charity WiafeCollege of Health Sciences, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), KNUST, Kumasi, Ghana.
Yaw Adu-SarkodieDepartment of Clinical Microbiology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Ellis Owusu-DaboCollege of Health Sciences, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), KNUST, Kumasi, Ghana.
Jürgen MayInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.
Daniel EibachInfectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfluenza surveillance data from Africa indicate a substantial disease burden with high mortality. However, local influenza data from district hospitals with limited laboratory facilities are still scarce.

objectivesTo identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.

methodsBetween January 2014 and April 2015, all children with a temperature of ≥38°C admitted to a district hospital in Ghana were screened for influenza A and B by RT-PCR and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.

resultsA total of 1063 children with a median age of 2 years (IQR: 1-4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (SARI) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09, and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3-5 years and was more frequently detected in the major rainy season (OR = 2.9; 95% CI: 1.47-6.19) during the first half of the year. Two (4%) and seven (15%) influenza-positive children were co-diagnosed with an invasive bloodstream infection or malaria, respectively.

conclusionInfluenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half-year.

Indexed as

Cost of IllnessBacteremiaBetainfluenzavirusChild, HospitalizedChild, PreschoolCoinfectionFemaleFeverGhanaHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMalariaMaleAfricabacteremiachildrenfeverinfluenzamalaria

Identifiers

PMID28991406
PMCPMC5705687

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.