Evidence map›Paper›PMID 28991268›Full record

ArticleNature biotechnology2017

Programmable assembly of pressure sensors using pattern-forming bacteria.

Yangxiaolu Cao, Yaying Feng, Marc D Ryser, Kui Zhu, Gregory Herschlag, Changyong Cao, Katherine Marusak, Stefan Zauscher, Lingchong You

Abstract read
In one paragraph

Article in Nature biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. De Novo Autogenic Engineered Living Functional Materials.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
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  7. The art of modeling gene regulatory circuits.NPJ systems biology and applications · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Engineered Living Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2022
    Review
  15. Review
  16. Article
  17. Frequency dependent growth of bacteria in living materials.Frontiers in bioengineering and biotechnology · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yangxiaolu CaoDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Yaying FengDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA.
Marc D RyserDepartment of Mathematics, Duke University, Durham, North Carolina, USA.
Kui ZhuDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Gregory HerschlagDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Changyong CaoDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA.
Katherine MarusakDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, USA.
Stefan ZauscherDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Lingchong YouDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.

Funding

Post-antibiotic effect and design of optimal antibiotic dosing protocolsR01GM098642 · NIGMS · DUKE UNIVERSITY · PI YOU, LINGCHONG · 2011 to 2025
$3.6M
Mathematical Models of Cancer Initiation, Progression, and Resistance to TherapyR01GM096190 · NIGMS · DUKE UNIVERSITY · PI DURRETT, RICK · 2010 to 2013
$1.4M
The Mathematics of Breast Cancer Overtreatment: Improving Treatment Choice through Effective Communication of Personalized Cancer RiskK99CA207872 · NCI · DUKE UNIVERSITY · PI RYSER, MARC · 2016 to 2017
$318k
NCI NIH HHS K99 CA207872NIGMS NIH HHS R01 GM096190NIGMS NIH HHS R01 GM098642
6 · The paper itself

Abstract

Biological systems can generate microstructured materials that combine organic and inorganic components and possess diverse physical and chemical properties. However, these natural processes in materials fabrication are not readily programmable. Here, we use a synthetic-biology approach to assemble patterned materials. We demonstrate programmable fabrication of three-dimensional (3D) materials by printing engineered self-patterning bacteria on permeable membranes that serve as a structural scaffold. Application of gold nanoparticles to the colonies creates hybrid organic-inorganic dome structures. The dynamics of the dome structures' response to pressure is determined by their geometry (colony size, dome height, and pattern), which is easily modified by varying the properties of the membrane (e.g., pore size and hydrophobicity). We generate resettable pressure sensors that process signals in response to varying pressure intensity and duration.

Indexed as

Biosensing TechniquesEscherichia coliGoldMetal NanoparticlesPressureGold

Identifiers

PMID28991268
PMCPMC6003419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.