ArticleNature structural & molecular biology2017
MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD
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Article in Nature structural & molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
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Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
- Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.Science advances · 2025Article
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- Epigenetic control of topoisomerase 1 activity presents a cancer vulnerability.Nature communications · 2025Article
- Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.BMC biology · 2024Article
- Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice.Scientific reports · 2023Article
- MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes.Cell death & disease · 2023Article
- High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.Cancers · 2023Article
- Histone H2A variants: Diversifying chromatin to ensure genome integrity.Seminars in cell & developmental biology · 2023Review
- Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing.Frontiers in oncology · 2023Review
- P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NADOxidative medicine and cellular longevity · 2023Article
- Using epigenomics to understand cellular responses to environmental influences in diseases.PLoS genetics · 2023Review
- MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells.Science advances · 2022Article
- The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes.Journal of cell science · 2022Article
- Therapeutic Potentials of Poly (ADP-Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Evolution of a histone variant involved in compartmental regulation of NAD metabolism.Nature structural & molecular biology · 2021Article
- MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR.Nature structural & molecular biology · 2021Article
- Epigenetic Regulation of Myogenesis: Focus on the Histone Variants.International journal of molecular sciences · 2021Review
- Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.Cell reports · 2021Article
- Article
- MacroH2A1.2 deficiency leads to neural stem cell differentiation defects and autism-like behaviors.EMBO reports · 2021Article
Corrections and comments
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Authors and funding
20 authors at 10 institutions in 4 countries.
Melanija Posavec MarjanovićProgramme of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Badalona, Spain.
Sarah Hurtado-BagèsDepartment of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Maximilian LassiInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Vanesa ValeroJosep Carreras Leukemia Research Institute (IJC), Campus ICO-Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Roberto MalinverniJosep Carreras Leukemia Research Institute (IJC), Campus ICO-Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Hélène DelageUniversité de Lyon, Centre de Recherche en Cancérologie de Lyon, Cancer Cell Plasticity Department, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France.
Miriam NavarroMetabolomics Platform, Department of Electronic Engineering (DEEEA), Universitat Rovira i Virgili, Tarragona, Spain.
David CorujoJosep Carreras Leukemia Research Institute (IJC), Campus ICO-Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Iva GuberovicJosep Carreras Leukemia Research Institute (IJC), Campus ICO-Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Julien DouetJosep Carreras Leukemia Research Institute (IJC), Campus ICO-Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Pau Gama-PerezDepartment of Physiological Sciences II, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Pablo M Garcia-RovesDepartment of Physiological Sciences II, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Ivan AhelSir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Andreas G LadurnerBiomedical Center Munich (BMC)-Physiological Chemistry, Center for Integrated Protein Science Munich, Munich Cluster for Systems Neurology, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.
Oscar YanesMetabolomics Platform, Department of Electronic Engineering (DEEEA), Universitat Rovira i Virgili, Tarragona, Spain.
Philippe BouvetUniversité de Lyon, Centre de Recherche en Cancérologie de Lyon, Cancer Cell Plasticity Department, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France.
Mònica SuelvesProgramme of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Badalona, Spain.
Raffaele TeperinoInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0001-8815-1409
J Andrew PospisilikMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Marcus BuschbeckProgramme of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Badalona, Spain.ORCID 0000-0002-3218-4567
Universitat Autònoma de Barcelona · ESCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESHelmholtz Zentrum München · DEUniversitat de Barcelona · ESUniversité Claude Bernard Lyon 1 · FRCenter for Integrated Protein Science Munich · DEInstitute of Predictive and Personalized Medicine of Cancer · ESMax Planck Institute of Immunobiology and Epigenetics · DEUniversitat Pompeu Fabra · ESUniversity of Oxford · GB
Funding
Cancer Research UK 22284Wellcome Trust
Abstract
Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD
Indexed as
Cell RespirationGene Expression Regulation, DevelopmentalMuscle DevelopmentAnimalsCell NucleusHistonesMiceMitochondriaNADHistonesmacroH2A histoneNAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.