Evidence map›Paper›PMID 28991040›Full record

ArticleMedicine and science in sports and exercise2018

Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults.

Ran Li, Jin Xia, X I Zhang, Wambui Grace Gathirua-Mwangi, Jianjun Guo, Yufeng Li, Steve McKenzie, Yiqing Song

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine and science in sports and exercise, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 16 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

203 citing papers in PubMed, 16 syntheses or guidelines pooled it, 385 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Trial
  18. Effect of calcifediol and cholecalciferol on muscle function in postmenopausal women: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Trial
  19. Trial
  20. Trial

143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ran LiSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
Jin XiaSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
X I ZhangSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
Wambui Grace Gathirua-MwangiSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
Jianjun GuoSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
Yufeng LiSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
Steve McKenzieSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
Yiqing SongSports Health and Rehabilitation Research Center, China Institute of Sport Science, Beijing, PEOPLE'S REPUBLIC OF CHINA.
China Institute of Sport Science · CNIndiana University – Purdue University Indianapolis · US

Funding

Racial/Ethnic Differences in 25(OH)D and PTH Levels and CVD among WomenR01HL113056 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI SONG, YIQING · 2013 to 2016
$1.8M
Research and Training for Behavioral Oncology InterventionsK05CA175048 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHAMPION, VICTORIA LEE · 2014 to 2018
$484k
NCI NIH HHS K05 CA175048NHLBI NIH HHS R01 HL113056
6 · The paper itself

Abstract

introductionRecent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse.

methodsWe aimed to prospectively examine individual and joint associations of low muscle mass and low muscle strength with all-cause mortality in a nationally representative sample. This study included 4449 participants age 50 yr and older from the National Health and Nutrition Examination Survey 1999 to 2002 with public use 2011 linked mortality files. Weighted multivariable logistic regression models were adjusted for age, sex, race, body mass index (BMI), smoking, alcohol use, education, leisure time physical activity, sedentary time, and comorbid diseases.

resultsOverall, the prevalence of low muscle mass was 23.1% defined by appendicular lean mass (ALM) and 17.0% defined by ALM/BMI, and the prevalence of low muscle strength was 19.4%. In the joint analyses, all-cause mortality was significantly higher among individuals with low muscle strength, whether they had low muscle mass (odds ratio [OR], 2.03; 95% confidence interval [CI], 1.27-3.24 for ALM; OR, 2.53; 95% CI, 1.64-3.88 for ALM/BMI) or not (OR, 2.66; 95% CI, 1.53-4.62 for ALM; OR, 2.17; 95% CI, 1.29-3.64 for ALM/BMI). In addition, the significant associations between low muscle strength and all-cause mortality persisted across different levels of metabolic syndrome, sedentary time, and LTPA.

conclusionsLow muscle strength was independently associated with elevated risk of all-cause mortality, regardless of muscle mass, metabolic syndrome, sedentary time, or LTPA among US older adults, indicating the importance of muscle strength in predicting aging-related health outcomes in older adults.

Indexed as

Body CompositionMortalityMuscle StrengthAgedBody Mass IndexExerciseFemaleHumansMaleMetabolic SyndromeMiddle AgedMuscle, SkeletalNutrition SurveysOrgan SizeRisk FactorsSedentary Behavior

Identifiers

PMID28991040
PMCPMC5820209
OpenAlexW2762920249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.