Evidence map›Paper›PMID 28990693›Full record

ArticleThe Laryngoscope2018

Impact of medialization laryngoplasty on dynamic nanomechanical vocal fold structure properties.

Gregory R Dion, Peter A Benedict, Paulo G Coelho, Milan R Amin, Ryan C Branski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Acoustics and aerodynamic effects following glottal and infraglottal medialization in an excised larynx model.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Medialization Laryngoplasty: A Review for Speech-Language Pathologists.Journal of speech, language, and hearing research : JSLHR · 2021
    Review
  6. Article
  7. Development of Excised Larynx.Journal of voice : official journal of the Voice Foundation · 2020
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gregory R DionNYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine.
Peter A BenedictNYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine.
Paulo G CoelhoDepartment of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York.
Milan R AminNYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine.
Ryan C BranskiNYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine.ORCID 0000-0003-1190-9036
New York University · USUnited States Army Medical Command · US

Funding

Optimal RNA-based therapeutics for vocal fold injury and fibrosisR01DC013277 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BRANSKI, RYAN COMFORT · 2014 to 2018
$2.3M
NIDCD NIH HHS R01 DC013277
6 · The paper itself

Abstract

objectives/hypothesisAlthough the primary goal of medialization laryngoplasty is to improve glottic closure, implant placement is also likely to alter the biomechanical properties of the vocal fold (VF). We sought to employ novel, nanoscale technology to quantify these properties following medialization based on the hypothesis that different medialization materials will likely yield differential biomechanical effects. STUDY

designEx vivo.

methodsNine pig larynges were divided into three groups: control, Silastic (Dow Corning, Midland, Michigan, U.S.A.) block medialization, or Gore-Tex (W.L. Gore & Associates, Newark, Delaware) medialization. Laryngoplasty was performed on excised, intact larynges. The larynges were then bisected in the sagittal plane and each subjected to dynamic nanomechanical analysis (nano-DMA) at nine locations using a 250-μm flat-tip punch and frequency sweep-load profile across the free edge of the VF and inferiorly along the conus elasticus.

resultsSilastic block and Gore-Tex implant introduced increased storage and loss moduli. Overall, storage moduli mean (maximum) increased from 38 kilopascals (kPa) (119) to 72 kPa (422) and 129 kPa (978) in control, Gore-Tex, and Silastic implants, respectively. Similarly, loss moduli increased from 13 kPa (43) to 22 kPa (201) and 31 kPa (165), respectively. Moduli values varied widely by location in the Silastic block and Gore-Tex groups. At the free VF edge, mean (maximum) storage moduli were lowest in the Gore-Tex group, 20 kPa (44); compared to control, 34.5 kPa (86); and Silastic, 157.9 kPa (978), with similar loss and complex moduli trends.

conclusionMedialization laryngoplasty altered VF structure biomechanical properties; Silastic and Gore-Tex implants differentially impact these properties. LEVEL OF EVIDENCE: NA. Laryngoscope, 128:1163-1169, 2018.

Indexed as

AnimalsBiomechanical PhenomenaDimethylpolysiloxanesFemaleLaryngoplastyPolytetrafluoroethyleneProstheses and ImplantsSwineVocal CordsbaysilonDimethylpolysiloxanesPolytetrafluoroethylenecomplex moduliLarynxloss modulimechanical testingstorage modulivocal foldvoice

Identifiers

PMID28990693
PMCPMC5891392
OpenAlexW2762917668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.