ArticleLasers in surgery and medicine2018
Spatiotemporal modeling of laser tissue soldering using photothermal nanocomposites.
Article in Lasers in surgery and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Skin repair and infection control in diabetic, obese mice using bioactive laser-activated sealants.Biomaterials · 2024Article
- In situ light-activated materials for skin wound healing and repair: A narrative review.Bioengineering & translational medicine · 2024Review
- Laser tissue soldering of the gastrointestinal tract: A systematic review LTS of the gastrointestinal tract.Heliyon · 2023Review
- Temporal evaluation of efficacy and quality of tissue repair upon laser-activated sealing.Bioengineering & translational medicine · 2023Article
- Antimicrobial laser-activated sealants for combating surgical site infections.Biomaterials science · 2021Article
- Copper-Eluting Fibers for Enhanced Tissue Sealing and Repair.ACS applied materials & interfaces · 2020Article
- Terahertz three-dimensional monitoring of nanoparticle-assisted laser tissue soldering.Biomedical optics express · 2020Article
- Light-Activated Tissue-Integrating Sutures as Surgical Nanodevices.Advanced healthcare materials · 2019Article
- Robot-assisted laser tissue soldering system.Biomedical optics express · 2018Article
- Rapid Soft Tissue Approximation and Repair using Laser-activated Silk Nanosealants.Advanced functional materials · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveLaser tissue soldering using photothermal solders is a technology that facilitates rapid sealing using heat-induced changes in the tissue and the solder material. The solder material is made of gold nanorods embedded in a protein matrix patch that can be placed over the tissue rupture site and heated with a laser. Although laser tissue soldering is an attractive approach for surgical repair, potential photothermal damage can limit the success of this approach. Development of predictive mathematical models of photothermal effects including cell death, can lead to more efficient approaches in laser-based tissue repair.
methodsWe describe an experimental and modeling investigation into photothermal solder patches for sealing porcine and mouse cadaver intestine sections using near-infrared laser irradiation. Spatiotemporal changes in temperature were determined at the surface as well as various depths below the patch. A mathematical model, based on the finite element method, predicts the spatiotemporal temperature distribution in the patch and surrounding tissue, as well as concomitant cell death in the tissue is described.
resultsFor both the porcine and mouse intestine systems, the model predicts temperatures that are quantitatively similar to the experimental measurements with the model predictions of temperature increase often being within a just a few degrees of experimental measurements.
conclusionThis mathematical model can be employed to identify optimal conditions for minimizing healthy cell death while still achieving a strong seal of the ruptured tissue using laser soldering. Lasers Surg. Med. 50:143-152, 2018. © 2017 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.