Evidence map›Paper›PMID 28990272›Full record

ArticleBJU international2018

Impact of bladder cancer on health-related quality of life.

Angela B Smith, Byron Jaeger, Laura C Pinheiro, Lloyd J Edwards, Hung-Jui Tan, Matthew E Nielsen, Bryce B Reeve

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in BJU international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 7 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 7 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Patient-reported outcomes in non-muscle invasive bladder cancer: a mixed-methods systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
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  11. Longitudinal data on health-related quality of life and its association with time to readmission in bladder perfusion patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Angela B SmithDepartment of Urology, UNC, Chapel Hill, NC, USA.ORCID 0000-0003-3930-9817
Byron JaegerDepartment of Biostatistics, Gillings School of Global Public Health, UNC, Chapel Hill, NC, USA.
Laura C PinheiroDepartment of Health Policy and Management, Gillings School of Global Public Health, UNC, Chapel Hill, NC, USA.
Lloyd J EdwardsDepartment of Biostatistics, Gillings School of Global Public Health, UNC, Chapel Hill, NC, USA.
Hung-Jui TanDepartment of Urology, UNC, Chapel Hill, NC, USA.
Matthew E NielsenDepartment of Urology, UNC, Chapel Hill, NC, USA.
Bryce B ReeveLineberger Comprehensive Cancer Center, Multidisciplinary Genitourinary Oncology, UNC, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify changes in health-related quality of life (HRQoL) after diagnosis of bladder cancer in older adults in comparison with a group of adults without bladder cancer (controls). PATIENTS AND

methodsData from the Surveillance, Epidemiology and End Results registries were linked with Medicare Health Outcomes Survey (MHOS) data. Medicare beneficiaries aged ≥65 years in the period 1998-2013, who were diagnosed with bladder cancer between baseline and follow-up through the MHOS, were matched with control subjects without cancer using propensity scores. Linear mixed models were used to estimate predictors of HRQoL changes.

resultsAfter matching, 535 patients with bladder cancer (458 non-muscle-invasive bladder cancer [NMIBC] and 77 with muscle-invasive bladder cancer [MIBC]) and 2 770 control subjects without cancer were identified. Both patients with NMIBC and those with MIBC reported significant declines in HRQoL scores over time vs controls: physical component summary -2 and -5.3 vs -0.4, respectively; bodily pain -1.9 and -3.6 vs -0.7; role physical -2.7 and -4.7 vs -0.7; general health -2.4 and -6.1 vs 0; vitality -1.2 and -3.5 vs -0.1; and social functioning -2.1 and -5.7 vs -0.8. All scores ranged from 0 to 100. When stratified by time since diagnosis, HRQoL improved over 1 year for some domains (role physical), but remained lower across most domains.

conclusionsAfter diagnosis, patients with bladder cancer experienced significant declines in physical, mental and social HRQoL relative to controls. Decrements were most pronounced among individuals with MIBC. Methods to better understand and address HRQoL decrements among patients with bladder cancer are needed.

Indexed as

Quality of LifeDepressionFemaleHumansMalePainPatient Reported Outcome MeasuresTreatment OutcomeUrinary Bladder Neoplasms#BCSM#BladderCancerhealth-related quality of lifepatient-reported outcomestreatment outcomeurinary bladder neoplasmsurological surgery

Identifiers

PMID28990272
OpenAlexW2761759076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.