Evidence map›Paper›PMID 28990249›Full record

ArticleCell proliferation2017

Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer.

Yawei Zhao, Lianzhi Cui, Yue Pan, Dan Shao, Xiao Zheng, Fan Zhang, Hansi Zhang, Kan He, Li Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yawei ZhaoDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.ORCID http://orcid.org/0000-0002-1689-5406
Lianzhi CuiDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Yue PanDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Dan ShaoDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Xiao ZhengDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Fan ZhangDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Hansi ZhangDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Kan HeDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Li ChenDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCytotoxic chemotherapy is an effective and traditional treatment of ovarian cancer. However, chemotherapy-induced apoptosis may also trigger and ultimately accelerate the repopulation of the small number of adjacent surviving cells. This study mainly focused on the tumour cell repopulation caused by chemotherapy in ovarian cancer and the adjunctive/synergistic effect of Berberine on the prevention of tumour repopulation. MATERIALS AND

methodsThe transwell system was used to mimic the co-culture of surviving ovarian cancer cells in the microenvironment of cytotoxic chemotherapy-treated dying cells. Tumour cell proliferation was observed by crystal violet staining. AA and PGE

resultsChemotherapy drug VP16 treatment triggered AA pathway, leading to the elevated PGE

conclusionsOur observation suggested that Berberine could inhibit the chemotherapy-induced repopulation of ovarian cancer cells by suppressing the AA pathway and phosphorylation of FAK. And these findings implicated a novel combined use of Berberine and chemotherapeutics, which might prevent ovarian cancer recurrence by abrogating early tumour repopulation.

Indexed as

ApoptosisArachidonic AcidBerberineCarcinoma, Ovarian EpithelialCell Line, TumorCell ProliferationCell SurvivalCoculture TechniquesDrug TherapyFemaleFocal Adhesion Kinase 1Gene Expression Regulation, NeoplasticHumansMetabolic Networks and PathwaysNeoplasms, Glandular and EpithelialOvarian NeoplasmsArachidonic AcidBerberineFocal Adhesion Kinase 1PTK2 protein, human

Identifiers

PMID28990249
PMCPMC6529084
OpenAlexW2763996773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.