ArticleMolecular medicine reports2017
Imperatorin possesses notable anti‑inflammatory activity in vitro and in vivo through inhibition of the NF‑κB pathway.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Gabapentin improves neuropathic pain in Minamata disease model rats.Environmental health and preventive medicine · 2024Article
- The Assessment of the Efficacy of Imperatorin in Reducing Overactive Bladder Symptoms.International journal of molecular sciences · 2023Article
- Imperatorin Inhibits Proliferation, Migration, and InflammationACS omega · 2022Article
- TheFrontiers in pharmacology · 2022Review
- Molecular Mechanism of theEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Imperatorin Interferes with LPS Binding to the TLR4 Co-Receptor and Activates the Nrf2 Antioxidative Pathway in RAW264.7 Murine Macrophage Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects.International journal of molecular sciences · 2020Review
- Imperatorin suppresses IL-1β-induced iNOS expression via inhibiting ERK-MAPK/AP1 signaling in primary human OA chondrocytes.International immunopharmacology · 2020Article
- Interventional effects of the direct application of "Sanse powder" on knee osteoarthritis in rats as determined from lipidomics via UPLC-Q-Exactive Orbitrap MS.Chinese medicine · 2020Article
- Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice.British journal of pharmacology · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imperatorin (IMT) is a furanocoumarin from the root of Phlomis younghusbandii (Lamiaceae) with various activities. In the present study, the anti‑inflammatory effects of IMT were evaluated by examining dimethylbenzene‑induced ear edema, acetic acid‑induced vascular permeability and by performing cotton pellet granuloma assessments in mice. In addition, the expression of pro‑inflammatory cytokines, including tumor necrosis factor (TNF)‑α, interleukin (IL)‑6 and IL‑1β, were detected using enzyme‑linked immunosorbent assay kits in mice and using reverse transcription polymerase chain reaction analysis in RAW 264.7 cells. The expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase‑2 (COX‑2), nuclear p65, cytosolic p65 and inhibitor of nuclear factor (NF)‑κB (IκB) in RAW 264.7 cells were determined using western blot analysis. The results showed that the oral administration of IMT significantly inhibited the inflammatory reactions and reduced the release of TNF‑α, IL‑6 and IL‑1β reactions and reduced and suppressed the mRNA expression of TNF‑A expressionact1o, and the protein expression of iNOS and COX‑2 in the RAW 264.7 cells. The results also indicated that IMT suppressed the activity of NF‑κB via upregulating p65 and IκB in the cytoplasm and downregulating p65 in the nucleus. In conclusion, IMT possessed notable anti‑inflammatory activities in vitro and in vivo through inhibiting the NF‑κB pathway.
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