ArticleLab on a chip2017
Controlled droplet discretization and manipulation using membrane displacement traps.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Probing T-cell activation in nanoliter tumor co-cultures using membrane displacement trap arrays.Integrative biology : quantitative biosciences from nano to macro · 2024Article
- Programmable Control of Nanoliter Droplet Arrays using Membrane Displacement Traps.Advanced materials technologies · 2023Article
- Deterministic assembly of chromosome ensembles in a programmable membrane trap array.Biofabrication · 2021Article
- Static array of droplets and on-demand recovery for biological assays.Biomicrofluidics · 2020Article
- Microfluidic Droplet-Storage Array.Micromachines · 2020Article
- Photoactivated Selective Release of Droplets from Microwell Arrays.ACS applied materials & interfaces · 2020Article
- A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation.Biomicrofluidics · 2020Article
- Enhanced sample filling and discretization in thermoplastic 2D microwell arrays using asymmetric contact angles.Biomicrofluidics · 2020Article
- Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips.Journal of analytical methods in chemistry · 2020Article
- A Scalable Random Access Micro-traps Array for Formation, Selective Retrieval and Capturing of Individual Droplets.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2019Article
- Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing.Lab on a chip · 2019Article
- Integrating Immunology and Microfluidics for Single Immune Cell Analysis.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
An innovative platform enabling complex discretization and manipulation of aqueous droplets is described. The system uses simple membrane displacement trap elements to perform multiple functions including droplet discretization, release, metering, capture, and merging. Multi-layer PDMS devices with membrane displacement trap arrays are used to discretize sample into nanoliter scale droplet volumes, and reliably manipulate individual droplets within the arrays. Performance is characterized for varying capillary number flows, membrane actuation pressures, trap and membrane geometries, and trapped droplet volumes, with operational domains established for each platform function. The novel approach to sample digitization and droplet manipulation is demonstrated through discretization of a dilute bacteria sample, metering of individual traps to generate droplets containing single bacteria, and merging of the resulting droplets to pair the selected bacteria within a single droplet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.