Evidence map›Paper›PMID 28989957›Full record

ArticleACS biomaterials science & engineering2017

Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells.

Nicholas M Molino, Medea Neek, Jo Anne Tucker, Edward L Nelson, Szu-Wen Wang

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  11. Article
  12. Biological Nanoparticles in Vaccine Development.Frontiers in bioengineering and biotechnology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas M MolinoDepartment of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697 USA.
Medea NeekDepartment of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697 USA.
Jo Anne TuckerDepartment of Medicine, University of California, Irvine, CA 92697 USA.
Edward L NelsonDepartment of Medicine, University of California, Irvine, CA 92697 USA.
Szu-Wen WangDepartment of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697 USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Nanoparticle-Modulated Response Against Tumor-Associated AntigensR21EB017995 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI WANG, SZU-WEN · 2014 to 2015
$380k
NCI NIH HHS P30 CA062203NIBIB NIH HHS R21 EB017995
6 · The paper itself

Abstract

Efficient delivery of antigens is of paramount concern in immunotherapies. We aimed to target antigen presenting cells (APCs) by conjugating CpG oligonucleotides to an E2 protein nanoparticle surface (CpG-PEG-E2). Compared to E2 alone, we observed ~4-fold increase of

Indexed as

biodistributionCpGdendritic cell targetingE2nanoparticle vaccineoligonucleotidepolyethylene glycol

Identifiers

PMID28989957
PMCPMC5630166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.