ArticleAdvanced biomedical research2017
The Effect of Levothyroxine on Serum Levels of Interleukin 10 and Interferon-gamma in Rat Model of Multiple Sclerosis.
Article in Advanced biomedical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Neuroprotective effects of levothyroxine on cognition deficits and memory in an experimental model of Huntington's disease in rats: An electrophysiological study.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Influence of hormones in multiple sclerosis: focus on the most important hormones.Metabolic brain disease · 2023Review
- Evaluation of the Relative Frequency of Epstein-Barr Virus Infection in Patients with Recurrent Breast Cancer Compared with Patients with Nonrecurrent Breast Cancer.Advanced biomedical research · 2023Article
- Evaluation of PD-L1 antigen expression using immunohistochemistry technique in medullary thyroid carcinoma samples.International journal of physiology, pathophysiology and pharmacology · 2023Article
- Evaluation of the serum level of osteoprotegerin and bone mineral density in postmenopausal women.International journal of physiology, pathophysiology and pharmacology · 2022Article
- Predictive value of number and volume of demyelinating plaques in treatment response in patients with multiple sclerosis treated with INF-B.American journal of neurodegenerative disease · 2022Article
- The efficacy of itraconazole, fluticasone and doxycycline in chronic rhinosinusitis.International journal of physiology, pathophysiology and pharmacology · 2022Article
- Alcohol and multiple sclerosis: an immune system-based review.International journal of physiology, pathophysiology and pharmacology · 2020Review
- Clinical and radiologic manifestation B-cell mediated autoimmune diseases of central nervous system.American journal of clinical and experimental immunology · 2020Article
- Effect of fingolimod on white blood cell, lymphocyte and neutrophil counts in MS patients.American journal of clinical and experimental immunology · 2019Article
- Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 1.International journal of physiology, pathophysiology and pharmacology · 2019Review
- Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 2.International journal of physiology, pathophysiology and pharmacology · 2019Review
- Fingolimod and changes in hematocrit, hemoglobin and red blood cells of patients with multiple sclerosis.American journal of clinical and experimental immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an increase in inflammatory and a reduction in anti-inflammatory cytokines in multiple sclerosis (MS). Considering the role of thyroid hormones in the development and regulation of both neural and immune systems, the aim of this study was to evaluate the effects of levothyroxine on serum concentrations of interleukin-10 (IL-10) and interferon gamma (IFN-γ) in animal models of MS. MATERIALS AND
methodsTo induce demyelination in male Wistar rats, lysolecithin was injected into the optic chiasm. Then levothyroxine was injected intraperitoneally (20, 50, and 100 μg/kg) for 21 days. Serum levels of cytokines were measured by enzyme-linked immunosorbent assay at 7, 14, and 21 days after that.
resultsThe results showed that injection of lysolecithin to the optic chiasm only increased serum concentrations of IL-10 compared to the sham group (
conclusionThe results showed that thyroid hormones probably could produce protective effects against induced demyelination through affecting immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.