Evidence map›Paper›PMID 28989863›Full record

ArticleBrain plasticity (Amsterdam, Netherlands)2015

Evaluation of a C57BL/6J × 129S1/SvImJ Hybrid Nestin-Thymidine Kinase Transgenic Mouse Model for Studying the Functional Significance of Exercise-Induced Adult Hippocampal Neurogenesis.

G F Hamilton, P Majdak, D S Miller, P J Bucko, J R Merritt, C P Krebs, J S Rhodes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain plasticity (Amsterdam, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Tracking Effects of Exercise on Neuronal Plasticity.Brain plasticity (Amsterdam, Netherlands) · 2015
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

G F HamiltonDepartment of Psychology, The Beckman Institute, 405N Mathews Ave, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
P MajdakDepartment of Psychology, The Beckman Institute, 405N Mathews Ave, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
D S MillerDepartment of Psychology, The Beckman Institute, 405N Mathews Ave, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
P J BuckoDepartment of Psychology, The Beckman Institute, 405N Mathews Ave, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
J R MerrittDepartment of Psychology, The Beckman Institute, 405N Mathews Ave, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
C P KrebsDepartment of Psychology, The Beckman Institute, 405N Mathews Ave, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
J S RhodesDepartment of Psychology, The Beckman Institute, 405N Mathews Ave, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
University of Illinois Urbana-Champaign · US

Funding

Mouse genetic differences in exercise-induced hippocampal neurogenesis & learningR01MH083807 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RHODES, JUSTIN S · 2009 to 2013
$1.4M
The functional significance of exercise-induced neurogenesis in cocaine rewardR01DA027487 · NIDA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RHODES, JUSTIN S · 2009 to 2013
$1.3M
NIDA NIH HHS R01 DA027487NIMH NIH HHS R01 MH083807
6 · The paper itself

Abstract

New neurons are continuously generated in the adult hippocampus but their function remains a mystery. The nestin thymidine kinase (nestin-TK) transgenic method has been used for selective and conditional reduction of neurogenesis for the purpose of testing the functional significance of new neurons in learning, memory and motor performance. Here we explored the nestin-TK model on a hybrid genetic background (to increase heterozygosity, and "hybrid vigor"). Transgenic C57BL/6J (B6) were crossed with 129S1/SvImJ (129) producing hybrid offspring (F1) with the B6 half of the genome carrying a herpes simplex virus thymidine kinase (TK) transgene regulated by a modified nestin promoter. In the presence of exogenously administered valganciclovir, new neurons expressing TK undergo apoptosis. Female B6 nestin-TK mice (

Indexed as

BrdUlearningmemorymorris water mazerotarodRunning

Identifiers

PMID28989863
PMCPMC5627510
OpenAlexW2211653167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.