Evidence map›Paper›PMID 28989647›Full record

ArticleChemical science2017

Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment.

A Matsumoto, A J Stephenson-Brown, T Khan, T Miyazawa, H Cabral, K Kataoka, Y Miyahara

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

A MatsumotoInstitute of Biomaterials and Bioengineering , Tokyo Medical and Dental University , 2-3-10 Kanda-Surugadai, Chiyoda-ku , Tokyo 101-0062 , Japan . Email: matsumoto.bsr@tmd.ac.jp.ORCID 0000-0002-7568-8677
A J Stephenson-BrownSchool of Chemical Engineering , University of Birmingham , Edgbaston , Birmingham , B15 2TT , UK.
T KhanDepartment of Bioengineering , Graduate School of Engineering , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku , Tokyo 113-8656 , Japan.
T MiyazawaInstitute of Biomaterials and Bioengineering , Tokyo Medical and Dental University , 2-3-10 Kanda-Surugadai, Chiyoda-ku , Tokyo 101-0062 , Japan . Email: matsumoto.bsr@tmd.ac.jp.
H CabralDepartment of Bioengineering , Graduate School of Engineering , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku , Tokyo 113-8656 , Japan.
K KataokaSchool of Chemical Engineering , University of Birmingham , Edgbaston , Birmingham , B15 2TT , UK.
Y MiyaharaInstitute of Biomaterials and Bioengineering , Tokyo Medical and Dental University , 2-3-10 Kanda-Surugadai, Chiyoda-ku , Tokyo 101-0062 , Japan . Email: matsumoto.bsr@tmd.ac.jp.
The University of Tokyo · JPTokyo Medical and Dental University · JPUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Boronic acids are well known for their ability to reversibly interact with the diol groups found in sugars and glycoproteins. However, they are generally indiscriminate in their binding. Herein we describe the discovery of a group of heterocyclic boronic acids demonstrating unusually high affinity and selectivity for sialic acids (SAs or

Identifiers

PMID28989647
PMCPMC5627601
OpenAlexW2726240392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.