Evidence map›Paper›PMID 28989646›Full record

ArticleChemical science2017

The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants.

Jing Yang, Xueli Zhang, Yiying Zhu, Emily Lenczowski, Yanli Tian, Jian Yang, Can Zhang, Markus Hardt, Chunhua Qiao, Rudolph E Tanzi and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Jing YangMolecular Imaging Laboratory , MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology , Massachusetts General Hospital , Harvard Medical School , Room 2301, Building 149, Charlestown , Boston , Massachusetts 02129 , USA . Email: cran@nmr.mgh.harvard.edu.
Xueli ZhangMolecular Imaging Laboratory , MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology , Massachusetts General Hospital , Harvard Medical School , Room 2301, Building 149, Charlestown , Boston , Massachusetts 02129 , USA . Email: cran@nmr.mgh.harvard.edu.
Yiying ZhuDepartment of Applied Oral Sciences , The Forsyth Institute , Cambridge , MA 02142 , USA.
Emily LenczowskiDepartment of Biology , Loyola University Chicago , Chicago , IL 60660 , USA . Email: hye1@luc.edu.
Yanli TianMolecular Imaging Laboratory , MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology , Massachusetts General Hospital , Harvard Medical School , Room 2301, Building 149, Charlestown , Boston , Massachusetts 02129 , USA . Email: cran@nmr.mgh.harvard.edu.
Jian YangMolecular Imaging Laboratory , MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology , Massachusetts General Hospital , Harvard Medical School , Room 2301, Building 149, Charlestown , Boston , Massachusetts 02129 , USA . Email: cran@nmr.mgh.harvard.edu.
Can ZhangAlzheimer's Disease Research Unit , Department of Neurology , Massachusetts General Hospital , Building 114 , Charlestown , Massachusetts 02129 , USA.
Markus HardtDepartment of Applied Oral Sciences , The Forsyth Institute , Cambridge , MA 02142 , USA.
Chunhua QiaoCollege of Pharmaceutical Sciences , Soochow University , Suzhou , 215006 , China.
Rudolph E TanziAlzheimer's Disease Research Unit , Department of Neurology , Massachusetts General Hospital , Building 114 , Charlestown , Massachusetts 02129 , USA.
Anna MooreMolecular Imaging Laboratory , MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology , Massachusetts General Hospital , Harvard Medical School , Room 2301, Building 149, Charlestown , Boston , Massachusetts 02129 , USA . Email: cran@nmr.mgh.harvard.edu.
Hui YeDepartment of Biology , Loyola University Chicago , Chicago , IL 60660 , USA . Email: hye1@luc.edu.
Chongzhao RanMolecular Imaging Laboratory , MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging , Department of Radiology , Massachusetts General Hospital , Harvard Medical School , Room 2301, Building 149, Charlestown , Boston , Massachusetts 02129 , USA . Email: cran@nmr.mgh.harvard.edu.ORCID 0000-0002-3892-4108
Harvard University · USLoyola University Chicago · USMassachusetts General Hospital · USSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological fate of amyloid beta (Aβ) species is a fundamental question in Alzheimer's disease (AD) pathogenesis. The competition between clearance and aggregation of Aβs is critical for the onset of AD. Copper has been widely considered to be an inducer of harmful crosslinking of Aβs, and an important triggering factor for the onset of AD. In this report, however, we present data to show that copper can also be an inducer of Aβ degradation in the presence of a large excess of well-known intrinsic (such as dopamine) or extrinsic (such as vitamin C) anti-oxidants. The degraded fragments were identified using SDS-Page gels, and validated

Identifiers

PMID28989646
PMCPMC5627602
OpenAlexW2658498731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.