Evidence map›Paper›PMID 28989616›Full record

ArticleChemical science2017

Synthesis and evaluation of MR probes for targeted-reporter imaging.

Kirti Dhingra Verma, Justin O Massing, Sarah G Kamper, Christiane E Carney, Keith W MacRenaris, James P Basilion, Thomas J Meade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Inorganic chemistry · 2025
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kirti Dhingra VermaDepartment of Biomedical Engineering , Case Center for Imaging Research , The NFCR Center for Molecular Imaging , Case Western Reserve University , Cleveland , Ohio 44106-7207 , USA.
Justin O MassingDepartment of Chemistry , Molecular Biosciences, Neurobiology , Biomedical Engineering, and Radiology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , USA.
Sarah G KamperDepartment of Chemistry , Molecular Biosciences, Neurobiology , Biomedical Engineering, and Radiology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , USA.
Christiane E CarneyDepartment of Chemistry , Molecular Biosciences, Neurobiology , Biomedical Engineering, and Radiology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , USA.
Keith W MacRenarisDepartment of Chemistry , Molecular Biosciences, Neurobiology , Biomedical Engineering, and Radiology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , USA.
James P BasilionDepartment of Biomedical Engineering , Case Center for Imaging Research , The NFCR Center for Molecular Imaging , Case Western Reserve University , Cleveland , Ohio 44106-7207 , USA.
Thomas J MeadeDepartment of Chemistry , Molecular Biosciences, Neurobiology , Biomedical Engineering, and Radiology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , USA.ORCID 0000-0001-6202-1155

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Small Animal Surgery and HistologyP01HL108795 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LOSORDO, DOUGLAS W · 2011 to 2015
$10.7M
Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
q-Modulated Magnetic Resonance Imaging Contrast AgentsR01EB005866 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2005 to 2013
$2.2M
NCI NIH HHS P30 CA060553NHLBI NIH HHS P01 HL108795NIBIB NIH HHS R01 EB005866NIGMS NIH HHS T32 GM008382
6 · The paper itself

Abstract

Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications.

Identifiers

PMID28989616
PMCPMC5621504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.