Evidence map›Paper›PMID 28989541›Full record

ArticleCellular and molecular bioengineering2016

A Parallel-Plate Flow Chamber for Mechanical Characterization of Endothelial Cells Exposed to Laminar Shear Stress.

Andrew K Wong, Pierre LLanos, Nickolas Boroda, Seth R Rosenberg, Sina Y Rabbany

Abstract read
In one paragraph

Article in Cellular and molecular bioengineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew K WongBioengineering Program, School of Engineering and Applied Science, Hofstra University, Hempstead, NY, 11549.
Pierre LLanosBioengineering Program, School of Engineering and Applied Science, Hofstra University, Hempstead, NY, 11549.
Nickolas BorodaBioengineering Program, School of Engineering and Applied Science, Hofstra University, Hempstead, NY, 11549.
Seth R RosenbergBioengineering Program, School of Engineering and Applied Science, Hofstra University, Hempstead, NY, 11549.
Sina Y RabbanyBioengineering Program, School of Engineering and Applied Science, Hofstra University, Hempstead, NY, 11549.

Funding

Identification of vascular-derived signals for alveolar lung repairR01HL119872 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2013 to 2016
$2.3M
NHLBI NIH HHS R01 HL119872
6 · The paper itself

Abstract

Shear stresses induced by laminar fluid flow are essential to properly recapitulate the physiological microenvironment experienced by endothelial cells (ECs). ECs respond to these stresses via mechanotransduction by modulating their phenotype and biomechanical characteristics, which can be characterized by Atomic Force Microscopy (AFM). Parallel Plate Flow Chambers (PPFCs) apply unidirectional laminar fluid flow to EC monolayers

Indexed as

actin remodelingAtomic Force Microscopycone-and-plate viscometer

Identifiers

PMID28989541
PMCPMC5629975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.