Evidence map›Paper›PMID 28989337›Full record

ArticleAdvanced functional materials2017

Neuroendocrine Tumor-Targeted Upconversion Nanoparticle-Based Micelles for Simultaneous NIR-Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging.

Guojun Chen, Renata Jaskula-Sztul, Corinne R Esquibel, Irene Lou, Qifeng Zheng, Ajitha Dammalapati, April Harrison, Kevin W Eliceiri, Weiping Tang, Herbert Chen and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 173 citations in OpenAlex.

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  14. Bistratal Au@BiBioactive materials · 2021
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  15. Recent Advances in Functional Carbon Quantum Dots for Antitumour.International journal of nanomedicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Guojun ChenDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA. Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA.
Renata Jaskula-SztulDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Corinne R EsquibelLaboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI 53706, USA.
Irene LouDepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53705, USA.
Qifeng ZhengDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA. Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA.
Ajitha DammalapatiDepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53705, USA.
April HarrisonDepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53705, USA.
Kevin W EliceiriWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA. Department of Biomedical Engineering University of Wisconsin-Madison, Madison, WI 53706, USA. Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI 53706, USA.
Weiping TangSchool of Pharmacy, University of Wisconsin-Madison, WI 53705, USA.
Herbert ChenDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Shaoqin GongDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA. Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA. Department of Biomedical Engineering University of Wisconsin-Madison Madison, WI 53706, USA.
University of Wisconsin–Madison · USWisconsin Institutes for Discovery · USUniversity of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
UW Surgical Oncology Research Training Program (UW-SORT)T32CA090217 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Muhammed Murtaza, Heather B Neuman · 2001 to 2026
$8.3M
GSK3-beta Signaling in Medullary Thyroid CancerR01CA121115 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CHEN, HERBERT · 2009 to 2013
$1.5M
Targeted Therapy of Neuroendocrine Cancers Via the Notch Signaling PathwayK25CA166178 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GONG, SHAOQIN - · 2013 to 2017
$994k
Targeting Triple Negative Breast Cancer Using Nanoparticles Loaded with the Anti-Cancer Drug AminoflavoneR21CA196653 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GONG, SHAOQIN -, XU, WEI · 2016 to 2017
$337k
NCI NIH HHS K25 CA166178NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA121115NCI NIH HHS R21 CA196653NCI NIH HHS T32 CA090217
6 · The paper itself

Abstract

Although neuroendocrine tumors (NETs) are slow growing, they are frequently metastatic at the time of discovery and no longer amenable to curative surgery, emphasizing the need for the development of other treatments. In this study, multifunctional upconversion nanoparticle (UCNP)-based theranostic micelles are developed for NET-targeted and near-infrared (NIR)-controlled combination chemotherapy and photodynamic therapy (PDT), and bioimaging. The theranostic micelle is formed by individual UCNP functionalized with light-sensitive amphiphilic block copolymers poly(4,5-dimethoxy-2-nitrobenzyl methacrylate)-polyethylene glycol (PNBMA-PEG) and Rose Bengal (RB) photosensitizers. A hydrophobic anticancer drug, AB3, is loaded into the micelles. The NIR-activated UCNPs emit multiple luminescence bands, including UV, 540 nm, and 650 nm. The UV peaks overlap with the absorption peak of photocleavable hydrophobic PNBMA segments, triggering a rapid drug release due to the NIR-induced hydrophobic-to-hydrophilic transition of the micelle core and thus enabling NIR-controlled chemotherapy. RB molecules are activated via luminescence resonance energy transfer to generate

Identifiers

PMID28989337
PMCPMC5630134
OpenAlexW2577429140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.