Evidence map›Paper›PMID 28989284›Full record

ArticleJournal of experimental neuroscience2017

An Exploration Into Short-Interval Maintenance of Adult Hemispheric Cortical Thickness at an Individual Brain Level.

John Wall, Hong Xie, Xin Wang

Abstract read
In one paragraph

Article in Journal of experimental neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John WallWilliam R. Bauer Human Brain MRI Laboratory, Department of Neurosciences, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA.
Hong XieWilliam R. Bauer Human Brain MRI Laboratory, Department of Neurosciences, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA.
Xin WangWilliam R. Bauer Human Brain MRI Laboratory, Departments of Psychiatry, Radiology, and Neurosciences, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA.

Funding

Study of early brain alterations that predict development of chronic PTSDR01MH110483 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WANG, XIN · 2016 to 2021
$3.8M
NIMH NIH HHS R01 MH110483
6 · The paper itself

Abstract

Adult cerebral cortical structure is thought to be statically maintained over short intervals. This view is based on group average findings but has never been studied at the individual level. This issue was examined with an unconventional longitudinal magnetic resonance imaging design which measured hemispheric mean cortical thickness of an adult man repeatedly at week intervals over 6 months. These measures were compared with measurement error estimates to test the current prediction that thickness measures would be statically maintained within measurement error variation. The results did not support this prediction. Thickness underwent incremental and decremental fluctuations which ranged up to 0.12 mm and 5.83% over week and multiweek intervals and which differed from measurement error variation. These exploratory analyses suggest a working hypothesis that short-interval cortical structural maintenance in an individual can involve fluctuations in thickness. If confirmed, this hypothesis has potential implications for cortical maintenance mechanisms and precision medicine approaches.

Indexed as

Allostasis/homeostasiscortical maintenanceMRI morphometryN-of-1precision medicineremodeling/turnover plasticity

Identifiers

PMID28989284
PMCPMC5624352

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.