ArticleDrugs & therapy perspectives : for rational drug selection and use2017
Stability of medicines after repackaging into multicompartment compliance aids: eight criteria for detection of visual alteration.
Article in Drugs & therapy perspectives : for rational drug selection and use, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Feasibility, acceptability and validity of electronic adherence monitoring among adolescents in Zimbabwe: a mixed methods study.BMC global and public health · 2026Article
- Accuracy of medication labels on community pharmacy-prepared dose administration aids: An observational study.Exploratory research in clinical and social pharmacy · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMulticompartment compliance aids (MCA) are widely used by patients. They support the management of medication and reduce unintentional nonadherence. MCA are filled with medicines unpacked from their original packaging. Swiss pharmacists currently provide MCA for 1-2 weeks, although little and controversial information exists on the stability of repackaged medicines.
objectiveWe aimed to validate the usefulness of a simple screening method capable of detecting visual stability problems with repackaged medicines.
methodsWe selected eight criteria for solid formulations from
resultsSix alterations (rough surface, cracking, mottling, discoloration, swelling, and crushing) were observed at accelerated conditions. No alteration was observed at room temperature, except for the chipping of tablets that had been stuck to cold seal glue.
conclusionThe eight criteria can detect alterations of the appearance of oral solid medicines repackaged in MCA. In the absence of specific guidelines, they can serve as a simple screening method in community pharmacies for identifying medicines unsuitable for repackaging.
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Registered trials
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