Evidence map›Paper›PMID 28988932›Full record

ArticleMolecular cell2017

6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase.

James Chen, Karen M Wassarman, Shili Feng, Katherine Leon, Andrey Feklistov, Jared T Winkelman, Zongli Li, Thomas Walz, Elizabeth A Campbell, Seth A Darst

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 83 citations in OpenAlex.

  1. Bacterial small regulatory RNAs.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Article
  4. Mechanism of mammalian transcriptional repression by noncoding RNA.Nature structural & molecular biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Mechanisms and regulation of human mitochondrial transcription.Nature reviews. Molecular cell biology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. RNAP Promoter Search and Transcription Kinetics in LiveThe journal of physical chemistry. B · 2023
    Article
  14. Probing the conformational changes ofFrontiers in molecular biosciences · 2023
    Article
  15. Article
  16. RNA (New York, N.Y.) · 2022
    Article
  17. Article
  18. Article
  19. Ms1 RNA Interacts With the RNA Polymerase Core inFrontiers in microbiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

James ChenLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Karen M WassarmanDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Shili FengLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Katherine LeonLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Andrey FeklistovLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Jared T WinkelmanDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Zongli LiHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Thomas WalzLaboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY 10065, USA.
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA. Electronic address: elizabeth.campbell0@gmail.com.
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA. Electronic address: darst@rockefeller.edu.
Rockefeller University · USUniversity of Wisconsin–Madison · USHoward Hughes Medical Institute · US

Funding

Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
MEDCHANISM, ACTIVATION, &CONTROL OF RRNA TRANSCRIPTIONR01GM037048 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GOURSE, RICHARD L. · 1986 to 2020
$5.9M
Regulation Of Transcription by 6S RNAR01GM067955 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WASSARMAN, KAREN M · 2003 to 2018
$3.6M
NIGMS NIH HHS R01 GM037048NIGMS NIH HHS R01 GM067955NIGMS NIH HHS R35 GM118130
6 · The paper itself

Abstract

Noncoding RNAs (ncRNAs) regulate gene expression in all organisms. Bacterial 6S RNAs globally regulate transcription by binding RNA polymerase (RNAP) holoenzyme and competing with promoter DNA. Escherichia coli (Eco) 6S RNA interacts specifically with the housekeeping σ

Indexed as

DNA, BacterialDNA, B-FormDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsRNA, BacterialRNA, UntranslatedSigma Factor6S RNADNA, BacterialDNA, B-FormDNA-Directed RNA PolymerasesEscherichia coli ProteinsRNA, BacterialRNA polymerase sigma 70RNA, UntranslatedSigma Factor6S RNAcryo-electron microscopynon-coding RNARNA polymerasetranscription regulation

Identifiers

PMID28988932
PMCPMC5683422
OpenAlexW2764077044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.