ArticleSchizophrenia research2018
DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review.Neurogenetics · 2024Pooled it
- A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Pooled it
- System-Specific Epigenetic Aging Signatures in Autistic Adults.bioRxiv : the preprint server for biology · 2026Article
- Deep Learning-Based Structural Brain Age Estimation in Bipolar Disorder and Schizophrenia: A Single-Site Pilot Study.Human brain mapping · 2026Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Meta-analyses of epigenetic age acceleration and GrimAge components of schizophrenia or first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2024Article
- Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder.Frontiers in genetics · 2024Article
- Epigenetic analysis suggests aberrant cerebellum brain aging in old-aged adults with autism spectrum disorder and schizophrenia.Molecular psychiatry · 2023Article
- The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health.Biological psychiatry · 2023Review
- Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder.Translational psychiatry · 2023Article
- Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients.BMC psychiatry · 2023Article
- Within subject cross-tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2023Article
- Subjective Overview of Accelerated Aging in Schizophrenia.International journal of environmental research and public health · 2022Review
- DNA methylation levels of RELN promoter region in ultra-high risk, first episode and chronic schizophrenia cohorts of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Antipsychotics function as epigenetic age regulators in human neuroblastoma cells.Schizophrenia (Heidelberg, Germany) · 2022Article
- Article
- Epigenetic clocks in relapse after a first episode of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Neurodegenerative model of schizophrenia: Growing evidence to support a revisit.Schizophrenia research · 2022Review
- Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging.Aging cell · 2021Article
- Older molecular brain age in severe mental illness.Molecular psychiatry · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Individuals with schizophrenia (SZ) exhibit multiple premature age-related phenotypes and die ~20years prematurely. The accelerated aging hypothesis of SZ has been advanced to explain these observations, it posits that SZ-associated factors accelerate the progressive biological changes associated with normal aging. Testing the hypothesis has been limited by the absence of robust, meaningful, and multi-tissue measures of biological age. Recently, a method was described in which DNA methylation (DNAm) levels at 353 genomic sites are used to produce "DNAm age", an estimate of biological age with advantages over existing measures. We used this method and 3 publicly-available DNAm datasets, 1 from brain and 2 from blood, to test the hypothesis. The brain dataset was composed of data from the dorsolateral prefrontal cortex of 232 non-psychiatric control (NPC) and 195 SZ subjects. Blood dataset #1 was composed of data from whole blood of 304 NPC and 332 SZ subjects, and blood dataset #2 was composed of data from whole blood of 405 NPC and 260 SZ subjects. DNAm age and chronological age correlated strongly (r=0.92-0.95, p<0.0001) in both NPC and SZ subjects in all 3 datasets. DNAm age acceleration did not differ between NPC and SZ subjects in the brain dataset (t=0.52, p=0.60), blood dataset #1 (t=1.51, p=0.13), or blood dataset #2 (t=0.93, p=0.35). Consistent with our previous findings from a smaller study of postmortem brains, our findings suggest there is no acceleration of brain or blood aging in SZ and, thus, do not support the accelerated aging hypothesis of SZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.