ArticleCurrent biology : CB2017
Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Optimization of connectome weights for a neural network model generating both forward and backward locomotion in C. elegans.Scientific reports · 2026Article
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- Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.Nature communications · 2026Article
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- RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses inFrontiers in molecular biosciences · 2024Article
- A cGAL-UAS bipartite expression toolkit forProceedings of the National Academy of Sciences of the United States of America · 2023Article
- An expanded GCaMP reporter toolkit for functional imaging in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- An expanded GCaMP reporter toolkit for functional imaging inbioRxiv : the preprint server for biology · 2023Article
- Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023Review
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- Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior.Current biology : CB · 2021Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Alanine tRNAs Translate Environment Into Behavior inFrontiers in cell and developmental biology · 2020Article
- A cellular defense memory imprinted by early life toxic stress.Scientific reports · 2019Article
- Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019Review
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3-7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.