Evidence map›Paper›PMID 28988580›Full record

ReviewAlcohol research : current reviews2017

Development, Prevention, and Treatment of Alcohol-Induced Organ Injury: The Role of Nutrition.

Shirish Barve, Shao-Yu Chen, Irina Kirpich, Walter H Watson, Craig Mcclain

Open access · greenAbstract readReview
In one paragraph

Review in Alcohol research : current reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Strongyloidiasis.Nature reviews. Disease primers · 2024
    Review
  18. Article
  19. Dietary cholesterol in alcohol-associated liver disease.Immunometabolism (Cobham, Surrey) · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shirish BarveShirish Barve, Ph.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology; Shao-Yu Chen, Ph.D., is a Professor in the Department of Pharmacology and Toxicology; Irina Kirpich, Ph.D., and Walter H. Watson, Ph.D., both are Assistant Professors in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and in the Department of Pharmacology and Toxicology; all at the University of Louisville School of Medicine, Louisville, Kentucky. Craig McClain, M.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology at the University of Louisville School of Medicine, Louisville, Kentucky, and a Staff Physician at the Robley Rex Veterans Medical Center, Louisville, Kentucky.
Shao-Yu ChenShirish Barve, Ph.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology; Shao-Yu Chen, Ph.D., is a Professor in the Department of Pharmacology and Toxicology; Irina Kirpich, Ph.D., and Walter H. Watson, Ph.D., both are Assistant Professors in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and in the Department of Pharmacology and Toxicology; all at the University of Louisville School of Medicine, Louisville, Kentucky. Craig McClain, M.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology at the University of Louisville School of Medicine, Louisville, Kentucky, and a Staff Physician at the Robley Rex Veterans Medical Center, Louisville, Kentucky.
Irina KirpichShirish Barve, Ph.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology; Shao-Yu Chen, Ph.D., is a Professor in the Department of Pharmacology and Toxicology; Irina Kirpich, Ph.D., and Walter H. Watson, Ph.D., both are Assistant Professors in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and in the Department of Pharmacology and Toxicology; all at the University of Louisville School of Medicine, Louisville, Kentucky. Craig McClain, M.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology at the University of Louisville School of Medicine, Louisville, Kentucky, and a Staff Physician at the Robley Rex Veterans Medical Center, Louisville, Kentucky.
Walter H WatsonShirish Barve, Ph.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology; Shao-Yu Chen, Ph.D., is a Professor in the Department of Pharmacology and Toxicology; Irina Kirpich, Ph.D., and Walter H. Watson, Ph.D., both are Assistant Professors in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and in the Department of Pharmacology and Toxicology; all at the University of Louisville School of Medicine, Louisville, Kentucky. Craig McClain, M.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology at the University of Louisville School of Medicine, Louisville, Kentucky, and a Staff Physician at the Robley Rex Veterans Medical Center, Louisville, Kentucky.
Craig McclainShirish Barve, Ph.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology; Shao-Yu Chen, Ph.D., is a Professor in the Department of Pharmacology and Toxicology; Irina Kirpich, Ph.D., and Walter H. Watson, Ph.D., both are Assistant Professors in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and in the Department of Pharmacology and Toxicology; all at the University of Louisville School of Medicine, Louisville, Kentucky. Craig McClain, M.D., is a Professor in the Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and a Professor in the Department of Pharmacology and Toxicology at the University of Louisville School of Medicine, Louisville, Kentucky, and a Staff Physician at the Robley Rex Veterans Medical Center, Louisville, Kentucky.
DSM (Netherlands) · NL

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Novel Therapies for Alcoholic HepatitisU01AA021893 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCCLAIN, CRAIG J., MCCULLOUGH, ARTHUR JOSEPH · 2012 to 2017
$6.0M
Role of microRNAs in Ethanol-induced Apoptosis and TeratogenesisR01AA021434 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2013 to 2017
$1.7M
The role of dietary unsaturated fat and inflammasome in alcoholic liver diseaseR01AA024102 · NIAAA · UNIVERSITY OF LOUISVILLE · PI KIRPICH, IRINA A. · 2016 to 2020
$1.7M
Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver InjuryU01AA022489 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, MCCLAIN, CRAIG J. · 2014 to 2018
$1.7M
Role of Siah1 in ethanol-induced apoptosis and teratogenesisR01AA020265 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2012 to 2016
$1.7M
Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseR01AA018869 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2009 to 2013
$1.7M
Mechanisms for alcohol induced gut barrier dysfunction in ALDR01AA023681 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2014 to 2018
$1.6M
SAM Deficiency Mediated Epigenetic Mechanisms in Alcohol induced ImmunosuppressionR01AA024405 · NIAAA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S · 2015 to 2019
$1.6M
Novel therapies in alcoholic hepatitis University of LouisvilleU01AA021901 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2012 to 2017
$1.5M
Dietary Fat in Ethanol-Induced Intestinal Barrier Dysfunction in ALDR21AA020849 · NIAAA · UNIVERSITY OF LOUISVILLE · PI KIRPICH, IRINA A. · 2012 to 2013
$381k
NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA018869NIAAA NIH HHS R01 AA020265NIAAA NIH HHS R01 AA021434NIAAA NIH HHS R01 AA023681NIAAA NIH HHS R01 AA024102NIAAA NIH HHS R01 AA024405NIAAA NIH HHS R21 AA020849NIAAA NIH HHS U01 AA021893NIAAA NIH HHS U01 AA021901NIAAA NIH HHS U01 AA022489NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

Alcohol and nutrition have the potential to interact at multiple levels. For example, heavy alcohol consumption can interfere with normal nutrition, resulting in overall malnutrition or in deficiencies of important micronutrients, such as zinc, by reducing their absorption or increasing their loss. Interactions between alcohol consumption and nutrition also can affect epigenetic regulation of gene expression by influencing multiple regulatory mechanisms, including methylation and acetylation of histone proteins and DNA. These effects may contribute to alcohol-related organ or tissue injury. The impact of alcohol-nutrition interactions has been assessed for several organs and tissues, including the intestine, where heavy alcohol use can increase intestinal permeability, and the liver, where the degree of malnutrition can be associated with the severity of liver injury and liver disease. Alcohol-nutrition interactions also play a role in alcohol-related lung injury, brain injury, and immune dysfunction. Therefore, treatment involving nutrient supplementation (e.g., with zinc or S-adenosylmethionine) may help prevent or attenuate some types of alcohol-induced organ damage.

Indexed as

Alcohol DrinkingAlcohol-Related DisordersDeficiency DiseasesAnimalsHumansNutritional Physiological Phenomena

Identifiers

PMID28988580
PMCPMC5513692
OpenAlexW2765266554

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.