Evidence map›Paper›PMID 28988573›Full record

ReviewAlcohol research : current reviews2017

Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.

Natalie M Zahr, Adolf Pfefferbaum

Open access · greenAbstract readReview
In one paragraph

Review in Alcohol research : current reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 2 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 2 syntheses or guidelines pooled it, 210 citations in OpenAlex.

  1. Pooled it
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  7. MAO-B status in alcohol use disorder: a [Molecular psychiatry · 2026
    Article
  8. Quantification of the neuropathology of alcohol use disorder using tissue microarrays.Journal of neuropathology and experimental neurology · 2026
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  10. Review
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Natalie M ZahrNatalie M. Zahr, Ph.D., is a Research Scientist in the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California; and Program Director of Translational Imaging, Neuroscience Program, SRI International, Menlo Park, California. Adolf Pfefferbaum, M.D., is Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine, Stanford, California; and Distinguished Scientist and Center Director of the Neuroscience Program, SRI International, Menlo Park, California.
Adolf PfefferbaumNatalie M. Zahr, Ph.D., is a Research Scientist in the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California; and Program Director of Translational Imaging, Neuroscience Program, SRI International, Menlo Park, California. Adolf Pfefferbaum, M.D., is Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine, Stanford, California; and Distinguished Scientist and Center Director of the Neuroscience Program, SRI International, Menlo Park, California.
SRI International · US

Funding

Neuroimaging of Alcohol-Induced Neuroadaptation: Translation From Animals to HumansU01AA013521 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 2001 to 2021
$15.2M
CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR01AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 1985 to 2025
$13.0M
NIAAA NIH HHS R01 AA005965NIAAA NIH HHS U01 AA013521
6 · The paper itself

Abstract

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence. In support of postmortem neuropathological studies showing degeneration of white matter, MRI studies have shown a specific vulnerability of white matter to chronic alcohol exposure. Such studies have demonstrated white-matter volume deficits as well as damage to selective gray-matter structures. Diffusion tensor imaging (DTI), by permitting microstructural characterization of white matter, has extended MRI findings in alcoholics. MR spectroscopy (MRS) allows quantification of several metabolites that shed light on brain biochemical alterations caused by alcoholism. This article focuses on MRI, DTI, and MRS findings in neurological disorders that commonly co-occur with alcoholism, including Wernicke's encephalopathy, Korsakoff's syndrome, and hepatic encephalopathy. Also reviewed are neuroimaging findings in animal models of alcoholism and related neurological disorders. This report also suggests that the dynamic course of alcoholism presents a unique opportunity to examine brain structural and functional repair and recovery.

Indexed as

Alcoholic Korsakoff SyndromeAnimalsDiffusion Tensor ImagingHepatic EncephalopathyHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyWernicke Encephalopathy

Identifiers

PMID28988573
PMCPMC5513685
OpenAlexW2593431579

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.