Evidence map›Paper›PMID 28988572›Full record

ReviewAlcohol research : current reviews2017

Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease.

Veronica Wendy Setiawan, Kristine Monroe, Aurelia Lugea, Dhiraj Yadav, Stephen Pandol

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in Alcohol research : current reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Coexistence of alcohol-related pancreatitis and alcohol-related liver disease: A systematic review and meta-analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020
    Pooled it
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  17. Binge Drinking's Effects on the Body.Alcohol research : current reviews · 2018
    Review
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  19. Extrahepatic Manifestations in Alcoholic Liver Disease.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Veronica Wendy SetiawanVeronica Wendy Setiawan, Ph.D., is an Assistant Professor at the Keck School of Medicine, University of Southern California, Los Angeles, California. Kristine Monroe, Ph.D., is an Associate Professor, at the Keck School of Medicine, University of Southern California, Los Angeles, California. Aurelia Lugea, Ph.D., is an Associate Professor at Cedars-Sinai Medical Center, Los Angeles, California. Dhiraj Yadav, M.D., M.P.H., is a Professor of Medicine in the Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Stephen J. Pandol, M.D., is Director of Basic and Translational Pancreas Research at Cedars-Sinai Medical Center, Los Angeles, California.
Kristine MonroeVeronica Wendy Setiawan, Ph.D., is an Assistant Professor at the Keck School of Medicine, University of Southern California, Los Angeles, California. Kristine Monroe, Ph.D., is an Associate Professor, at the Keck School of Medicine, University of Southern California, Los Angeles, California. Aurelia Lugea, Ph.D., is an Associate Professor at Cedars-Sinai Medical Center, Los Angeles, California. Dhiraj Yadav, M.D., M.P.H., is a Professor of Medicine in the Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Stephen J. Pandol, M.D., is Director of Basic and Translational Pancreas Research at Cedars-Sinai Medical Center, Los Angeles, California.
Aurelia LugeaVeronica Wendy Setiawan, Ph.D., is an Assistant Professor at the Keck School of Medicine, University of Southern California, Los Angeles, California. Kristine Monroe, Ph.D., is an Associate Professor, at the Keck School of Medicine, University of Southern California, Los Angeles, California. Aurelia Lugea, Ph.D., is an Associate Professor at Cedars-Sinai Medical Center, Los Angeles, California. Dhiraj Yadav, M.D., M.P.H., is a Professor of Medicine in the Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Stephen J. Pandol, M.D., is Director of Basic and Translational Pancreas Research at Cedars-Sinai Medical Center, Los Angeles, California.
Dhiraj YadavVeronica Wendy Setiawan, Ph.D., is an Assistant Professor at the Keck School of Medicine, University of Southern California, Los Angeles, California. Kristine Monroe, Ph.D., is an Associate Professor, at the Keck School of Medicine, University of Southern California, Los Angeles, California. Aurelia Lugea, Ph.D., is an Associate Professor at Cedars-Sinai Medical Center, Los Angeles, California. Dhiraj Yadav, M.D., M.P.H., is a Professor of Medicine in the Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Stephen J. Pandol, M.D., is Director of Basic and Translational Pancreas Research at Cedars-Sinai Medical Center, Los Angeles, California.
Stephen PandolVeronica Wendy Setiawan, Ph.D., is an Assistant Professor at the Keck School of Medicine, University of Southern California, Los Angeles, California. Kristine Monroe, Ph.D., is an Associate Professor, at the Keck School of Medicine, University of Southern California, Los Angeles, California. Aurelia Lugea, Ph.D., is an Associate Professor at Cedars-Sinai Medical Center, Los Angeles, California. Dhiraj Yadav, M.D., M.P.H., is a Professor of Medicine in the Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Stephen J. Pandol, M.D., is Director of Basic and Translational Pancreas Research at Cedars-Sinai Medical Center, Los Angeles, California.

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Vector and Human Acinar CoreP01DK098108 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2014 to 2018
$8.1M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL · 2012 to 2016
$6.2M
Alcohol abuse and Endoplasmic Reticulum dysfunction in exocrine pancreasR01AA019954 · NIAAA · CEDARS-SINAI MEDICAL CENTER · PI LUGEA, AURELIA · 2011 to 2015
$1.7M
BLRD VA I01 BX004306NCI NIH HHS P01 CA163200NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA019954NIDDK NIH HHS P01 DK098108NIDDK NIH HHS U01 DK108306
6 · The paper itself

Abstract

Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Intriguingly, a very low percentage of drinkers develop clinical pancreatitis. Experimental models demonstrate that alcohol administration alone does not initiate pancreatitis but does sensitize the pancreas to disease. Understanding the effects of alcohol use on the pancreas may prove beneficial in the prevention of both pancreatitis and pancreatic cancer.

Indexed as

Disease Models, AnimalPancreatitis, AlcoholicAnimalsHumans

Identifiers

PMID28988572
PMCPMC5513684

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.