ArticleAutoimmunity2017
Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome.
Article in Autoimmunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Age-related changes in the parotid gland: a computed tomography-based radiomics study.Quantitative imaging in medicine and surgery · 2026Article
- Adiponectin is associated with inflammaging and age-related salivary gland lipid accumulation.Aging · 2023Article
- Histopathology, salivary flow and ultrasonography of the parotid gland: three complementary measurements in primary Sjögren's syndrome.Rheumatology (Oxford, England) · 2022Article
- Inflammatory Stratification in Primary Sjögren's Syndrome Reveals Novel Immune Cell Alterations in Patients' Minor Salivary Glands.Frontiers in immunology · 2021Article
- Recent Advances of Salivary Gland Biopsy in Sjögren's Syndrome.Frontiers in medicine · 2021Review
- Imaging in Primary Sjögren's Syndrome.Journal of clinical medicine · 2020Review
- Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren's syndrome condition.Autoimmunity · 2020Article
- Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome.Frontiers in immunology · 2020Article
- Labial salivary gland biopsy and secondary Sjögren's syndrome: where we are and where we want to be.Reumatologia · 2019Article
- Current concepts on Sjögren's syndrome - classification criteria and biomarkers.European journal of oral sciences · 2018Review
- Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveDetermine the presence and assess the extent of fatty infiltration of the minor salivary glands (SG) of primary SS patients (pSS) as compared to those with non-SS sicca (nSS).
methodsMinor SG biopsy samples from 134 subjects with pSS (n = 72) or nSS (n = 62) were imaged. Total area and fatty replacement area for each glandular cross-section (n = 4-6 cross-sections per subject) were measured using Image J (National Institutes of Health, Bethesda, MD). The observer was blinded to subject classification status. The average area of fatty infiltration calculated per subject was evaluated by logistic regression and general linearized models (GLM) to assess relationships between fatty infiltration and clinical exam results, extent of fibrosis and age.
resultsThe average area of fatty infiltration for subjects with pSS (median% (range) 4.97 (0.05-30.2)) was not significantly different from that of those with nSS (3.75 (0.087-41.9). Infiltration severity varied widely, and subjects with fatty replacement greater than 6% were equivalently distributed between pSS and nSS participants (χ
conclusionsFatty infiltration is an age-associated phenomenon and not a selective feature of Sjögren's syndrome. Sicca patients who do not fulfil pSS criteria have similar rates of fatty infiltration of the minor SG.
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