Trial reportClinical oral investigations2018
Partial caries removal in deep caries lesions: a 5-year multicenter randomized controlled trial.
Trial report in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250142 (Effect of Pulp Protection After Selective Carious Tissue Removal in Permanent Teeth, a Randomized Controlled Clinical Trial), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Pulp Protection After Selective Carious Tissue Removal in Permanent Teeth, a Randomized Controlled Clinical Trial
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Comparative Meta-Analysis of Minimally Invasive and Conventional Approaches for Caries Removal in Permanent Dentition.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Interventions for treating cavitated or dentine carious lesions.The Cochrane database of systematic reviews · 2021Pooled it
- Selective, stepwise, or nonselective removal of carious tissue: which technique offers lower risk for the treatment of dental caries in permanent teeth? A systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Three-Year Clinical and Economic Evaluation of Selective Caries Removal and Full Pulpotomy for Extensive Caries: An Exploratory Randomised Controlled Trial.International endodontic journal · 2026Trial
- Calcium silicate liner versus no liner in selective caries removal: a one-year randomized clinical trial.BMC oral health · 2026Trial
- Selective removal of dental caries in permanent teeth: an 18-month clinical trial.Clinical oral investigations · 2025Trial
- Effect of photobiomodulation and selective caries removal in deep cavities on postoperative sensitivity, pulp vitality and dentin neoformation: randomized clinical trial and tomographic evaluation.Clinical oral investigations · 2025Trial
- Clinical outcomes of selective removal to soft dentin versus firm dentin for deep caries lesions: a randomized controlled trial up to 5 years.Clinical oral investigations · 2024Trial
- Outcome of vital pulp therapy in deeply carious molars affected with molar incisor hypomineralisation (MIH) defects: a randomized clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Trial
- Selective vs stepwise removal of deep carious lesions in primary molars: 24 months follow-up from a randomized controlled trial.Clinical oral investigations · 2021Trial
- Trial
- Complete, Selective, and Stepwise Carious Tissue Removal for Deep Carious Lesions in Vital Permanent Teeth: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- From Caries to Periodontal Breakdown: A Biological and Clinical Continuum Linking Cariology, Operative Dentistry, Endodontics, and Periodontology.Dentistry journal · 2026Review
- Optimization of Er: YAG pulse duration and repetition rate for efficient, dentin‑preserving caries removal.Lasers in medical science · 2026Article
- Long-Term Treatment Success Rate after Stepwise Caries Removal: A Registry Study.Caries research · 2026Article
- Management of deep caries.British dental journal · 2026Review
- On the necessity of complete caries excavation: a narrative review.Head & face medicine · 2025Review
- Intrafamilial Patterns of Oral Health: A Cross-Sectional Study of Dental Status Associations Among Children, Parents, and Siblings.Journal of clinical medicine · 2025Article
- Review
- Selective caries removal and management of exposed pulp in fully developed and immature teeth with reversible pulpitis: a questionnaire-based study in Greece.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThis multicenter randomized controlled clinical trial aimed to compare the outcomes of stepwise excavation (SW) and partial caries removal (PCR) regarding the maintenance of pulp vitality in deep caries lesions over 5 years.
methodsAt baseline, 299 permanent molars with deep caries lesions were randomly assigned to control or test groups. The control group received the stepwise excavation treatment (SW), while the test group received partial caries removal from the pulpal wall followed by restoration in a single session (PCR). Treatments were conducted in two centers located in the cities of Porto Alegre (South Brazil) and Brasília (Midwest Brazil). Survival analysis was performed to compare PCR and SW over time (Weibull regression models). The primary outcome of this study was pulp vitality, determined by the combination of the following characteristics: positive response to cold test, negative response to percussion, absence of spontaneous pain, and absence of periapical lesion (radiographic examination).
resultsThis 5-year study includes data pertaining to 229 teeth: 121 teeth actually examined at the 5-year appointment, and 108 teeth contributed with data collected in previous follow-ups (18 months or 3 years). Survival analysis showed success rates of 80% in PCR group and 56% in SW group (p < 0.001). Failure was significantly associated with treatment [PCR, HR=0.38; 95%CI=0.23-0.63)] and region [South, HR=2.22; 95%CI=1.21-4.08].
conclusionPCR significantly reduced the occurrence of pulp necrosis when compared with SW. CLINICAL RELEVANCE: This study supports the PCR as a single-visit technique to manage deep caries lesions in permanent teeth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.