SynthesisActa neurochirurgica2017
A systematic review of cerebral microdialysis and outcomes in TBI: relationships to patient functional outcome, neurophysiologic measures, and tissue outcome.
Synthesis in Acta neurochirurgica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 83 citations in OpenAlex.
- Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Trial
- Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury.Journal of neuroinflammation · 2021Trial
- Intracerebral Glutamate and Glycerol in Severe Acute Brain Injury: Retrospective Study of Association With Neuroworsening and Outcome.Acta anaesthesiologica Scandinavica · 2026Observational
- Region-specific proteomic profiling of brain interstitial fluidLab on a chip · 2026Article
- Association of cerebral microdialysis monitoring with clinical outcomes after traumatic brain injury; A systematic review.Brain & spine · 2026Review
- Traumatic Brain Injury: Advances in Diagnostic Techniques and Treatment Modalities.Journal of clinical medicine · 2025Review
- Brain Oxygenation and Metabolism Monitoring in Acute Brain Injury: Review on Current Trends and Clinical Implications.Korean journal of neurotrauma · 2025Review
- Unlocking the potential of high-resolution multimodality neuromonitoring for traumatic brain injury management: lessons and insights from cases, events, and patterns.Critical care (London, England) · 2025Review
- Multinuclear MRI Can Depict Metabolic and Energetic Changes in Mild Traumatic Brain Injury.NMR in biomedicine · 2025Article
- Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Traumatic brain injury: Advances in coagulopathy (Review).Biomedical reports · 2024Review
- Brain hypoxia and metabolic crisis are common in patients with acute brain injury despite a normal intracranial pressure.Scientific reports · 2024Observational
- Tracing the path of disruption:CNS neuroscience & therapeutics · 2024Review
- Article
- Management Strategies Based on Multi-Modality Neuromonitoring in Severe Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Multimodal Neuromonitoring in Pediatric Neurocritical Care: Current Perspectives.Indian journal of pediatrics · 2023Review
- A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury: The Next Step in Precision Medicine?Neurotrauma reports · 2023Article
- Current state of high-fidelity multimodal monitoring in traumatic brain injury.Acta neurochirurgica · 2022Review
- Traumatic brain injury: progress and challenges in prevention, clinical care, and research.The Lancet. Neurology · 2022Review
- Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass.Metabolites · 2022Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo perform a systematic review on commonly measured cerebral microdialysis (CMD) analytes and their association to: (A) patient functional outcome, (B) neurophysiologic measures, and (C) tissue outcome; after moderate/severe TBI. The aim was to provide a foundation for next-generation CMD studies and build on existing pragmatic expert guidelines for CMD.
methodsWe searched MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016). Strength of evidence was adjudicated using GRADE.
results(A) Functional Outcome: 55 articles were included, assessing outcome as mortality or Glasgow Outcome Scale (GOS) at 3-6 months post-injury. Overall, there is GRADE C evidence to support an association between CMD glucose, glutamate, glycerol, lactate, and LPR to patient outcome at 3-6 months. (B) Neurophysiologic Measures: 59 articles were included. Overall, there currently exists GRADE C level of evidence supporting an association between elevated CMD measured mean LPR, glutamate and glycerol with elevated ICP and/or decreased CPP. In addition, there currently exists GRADE C evidence to support an association between elevated mean lactate:pyruvate ratio (LPR) and low PbtO
conclusionsThis systematic review replicates previously documented relationships between CMD and various outcome, which have driven clinical application of the technique. Evidence assessments do not address the application of CMD for exploring pathophysiology or titrating therapy in individual patients, and do not account for the modulatory effect of therapy on outcome, triggered at different CMD thresholds in individual centers. Our findings support clinical application of CMD and refinement of existing guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.