ReviewCurrent environmental health reports2017
Potential Sex Differences Relative to Autism Spectrum Disorder and Metals.
Review in Current environmental health reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Hair Metals and Essential Trace Element Profiles in Children With Autism Spectrum Disorder (F84.0): an Exploratory Case-Control Study With Sex Stratified Descriptive Analyses.Biological trace element research · 2026Article
- Review
- Associations of prenatal metal exposures with autism-related outcomes in the ECHO cohort.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Associations between maternal occupational history and autism spectrum disorder diagnosis in offspring in Denmark.Occupational and environmental medicine · 2026Article
- Assessing Heavy Metal Contamination in Food: Implications for Human Health and Environmental Safety.Toxics · 2025Review
- Invited Perspective: Protect and Serve-The Potential Role of Folate in Lead Risk Reduction.Environmental health perspectives · 2024Article
- Association between Autism Spectrum Disorder, Trace Elements, and Intracranial Fluid Spaces.International journal of molecular sciences · 2024Article
- Prenatal Metal Exposures and Child Social Responsiveness Scale Scores in 2 Prospective Studies.Environmental health insights · 2024Article
- Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis.Biomedicines · 2023Review
- Review
- Hair Trace Elements and Mineral Content in Moroccan Children with Autism Spectrum Disorder: a Case-Control Study.Biological trace element research · 2023Article
- Prenatal socioenvironmental exposures and autism spectrum disorder: A web of confusion.Child development perspectives · 2023Article
- Exposing the role of metals in neurological disorders: a focus on manganese.Trends in molecular medicine · 2022Review
- Association between urinary cadmium concentrations and liver function in adolescents.Environmental science and pollution research international · 2022Article
- Validation of in vivo toenail measurements of manganese and mercury using a portable X-ray fluorescence device.Journal of exposure science & environmental epidemiology · 2022Article
- Particulate Matter and Associated Metals: A Link with Neurotoxicity and Mental Health.Atmosphere · 2021Article
- Evaluation of Zn, Cu, and Se Levels in the North American Autism Spectrum Disorder Population.Frontiers in molecular neuroscience · 2021Article
- Periconceptional and prenatal exposure to metal mixtures in relation to behavioral development at 3 years of age.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review.Frontiers in molecular neuroscience · 2020Article
- Toenail Metal Exposures in Fishermen from Bodo City, Nigeria.Bulletin of environmental contamination and toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis study aims to summarize the current body of literature on the relationship between various toxic metals exposures (i.e., aluminum, antimony, arsenic, beryllium, cadmium, chromium, lead, manganese, and nickel) and autism spectrum disorder (ASD), with a focus on potential sex differences in these associations. RECENT
findingsSex differences in ASD diagnosis and mutagenic effects of toxic exposures indicate that sex differences may play a major part in the causal relationship of any potential associations seen; however, we were only able to find three studies that reported on sex differences in observed associations with toxic metals exposure and ASD. We also found several studies investigating associations between ASD and metals exposures, including 11 on aluminum, 6 on antimony, 15 on arsenic, 5 on beryllium, 17 on cadmium, 11 on chromium, 25 on lead, 14 on manganese, and 13 on nickel with markers of exposure in hair, urine, blood, teeth, fingernails, and air pollution. Results for each metal were conflicting, but studies on cadmium and lead yielded the highest proportion of studies with positive results (72% and 36%, respectively). Based on our examination of existing literature, the current evidence warrants a considerable need for evaluations of sex differences in future studies assessing the association between metals exposures and ASD. Additionally, failure to account for potential sex differences could result in bias and misinterpretation of exposure-disease relationships.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.