Evidence map›Paper›PMID 28988291›Full record

ReviewCurrent environmental health reports2017

Statistical Approaches to Address Multi-Pollutant Mixtures and Multiple Exposures: the State of the Science.

Massimo Stafoggia, Susanne Breitner, Regina Hampel, Xavier Basagaña

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current environmental health reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Systematic review and meta-analysis on the health effects of long-term exposure to ultrafine particles.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Pooled it
  3. Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PMResearch report (Health Effects Institute) · 2021
    Pooled it
  4. Pooled it
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  19. Mixture analysis identifies ozone as driving factor for child asthma symptoms.The journal of allergy and clinical immunology. Global · 2025
    Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Massimo StafoggiaDepartment of Epidemiology, Lazio Region Health Service/ASL Roma 1, Via Cristoforo Colombo 112, 00147, Rome, Italy. m.stafoggia@deplazio.it.
Susanne BreitnerInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Neurherberg, Germany.
Regina HampelInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Neurherberg, Germany.
Xavier BasagañaISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to describe the most recent statistical approaches to estimate the effect of multi-pollutant mixtures or multiple correlated exposures on human health. RECENT

findingsThe health effects of environmental chemicals or air pollutants have been widely described. Often, there exists a complex mixture of different substances, potentially highly correlated with each other and with other (environmental) stressors. Single-exposure approaches do not allow disentangling effects of individual factors and fail to detect potential interactions between exposures. In the last years, sophisticated methods have been developed to investigate the joint or independent health effects of multi-pollutant mixtures or multiple environmental exposures. A classification of the most recent methods is proposed. A non-technical description of each method is provided, together with epidemiological applications and operational details for implementation with standard software.

Indexed as

Models, StatisticalAir PollutantsAir PollutionComplex MixturesEnvironmental ExposureEnvironmental MonitoringEnvironmental PollutantsHumansRisk AssessmentAir PollutantsComplex MixturesEnvironmental PollutantsCorrelated variablesEnvironmental exposuresEpidemiologyHealthMulti-pollutant

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.