Evidence map›Paper›PMID 28988290›Full record

ReviewCellular and molecular life sciences : CMLS2018

Early microbiota, antibiotics and health.

Alicja M Nogacka, Nuria Salazar, Silvia Arboleya, Marta Suárez, Nuria Fernández, Gonzalo Solís, Clara G de Los Reyes-Gavilán, Miguel Gueimonde

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Early-life antibiotics and childhood allergy: a multi-center cohort.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  3. Article
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  6. Article
  7. Article
  8. Review
  9. Review
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  11. Shaping Microbiota During the First 1000 Days of Life.Advances in experimental medicine and biology · 2024
    Review
  12. Article
  13. Review
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Dietary Supplementation with Goji Berries (Animals : an open access journal from MDPI · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Alicja M NogackaDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Asturias, Spain.
Nuria SalazarDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Asturias, Spain.
Silvia ArboleyaAPC Microbiome Institute, University College Cork, Cork, Ireland.
Marta SuárezPediatrics Service, Hospital Universitario Central de Asturias, SESPA, Oviedo, Asturias, Spain.
Nuria FernándezPediatrics Service, Hospital Universitario Central de Asturias, SESPA, Oviedo, Asturias, Spain.
Gonzalo SolísPediatrics Service, Hospital Universitario Central de Asturias, SESPA, Oviedo, Asturias, Spain.
Clara G de Los Reyes-GavilánDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Asturias, Spain.
Miguel GueimondeDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Asturias, Spain. mgueimonde@ipla.csic.es.
Hospital Universitario Central de Asturias · ESConsejo Superior de Investigaciones Científicas · ESInstituto de Productos Lácteos de Asturias · ESAPC Microbiome Institute · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The colonization of the neonatal digestive tract provides a microbial stimulus required for an adequate maturation towards the physiological homeostasis of the host. This colonization, which is affected by several factors, begins with facultative anaerobes and continues with anaerobic genera. Accumulating evidence underlines the key role of the early neonatal period for this microbiota-induced maturation, being a key determinant factor for later health. Therefore, understanding the factors that determine the establishment of the microbiota in the infant is of critical importance. Exposure to antibiotics, either prenatally or postnatally, is common in early life mainly due to the use of intrapartum prophylaxis or to the administration of antibiotics in C-section deliveries. However, we are still far from understanding the impact of early antibiotics and their long-term effects. Increased risk of non-communicable diseases, such as allergies or obesity, has been observed in individuals exposed to antibiotics during early infancy. Moreover, the impact of antibiotics on the establishment of the infant gut resistome, and on the role of the microbiota as a reservoir of resistance genes, should be evaluated in the context of the problems associated with the increasing number of antibiotic resistant pathogenic strains. In this article, we review and discuss the above-mentioned issues with the aim of encouraging debate on the actions needed for understanding the impact of early life antibiotics upon human microbiota and health and for developing strategies aimed at minimizing this impact.

Indexed as

Anti-Bacterial AgentsBacteriaGastrointestinal MicrobiomeGastrointestinal TractHumansMicrobial InteractionsTime FactorsAnti-Bacterial AgentsAntibioticsInfantIntrapartum-antimicrobial-prophylaxisMicrobiota

Identifiers

PMID28988290
PMCPMC11105232
OpenAlexW2761866677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.